نتایج جستجو برای: cytotoxic t lymphocyte ctl

تعداد نتایج: 770899  

1998
Robert T. Schooley Daniel R. Kuritzkes Elizabeth J. McFarland Paul A. Harding Samantha MaWhinney

Journal: :The Journal of Experimental Medicine 1996
A Y Huang A T Bruce D M Pardoll H I Levitsky

Tumors engineered to express the costimulatory molecule B7-1 can elicit CD8+ cytotoxic T lymphocyte (CTL)-dependent antitumor responses in immunocompetent mice. It has been postulated that this result reflects direct priming of CTL by the modified tumor in vivo. Previous studies of the immune response to a B7-1- murine colon carcinoma expressing influenza nucleoprotein (NP) as a model tumor ant...

Journal: :Journal of virology 1997
M A Brehm R H Bonneau D M Knipe S S Tevethia

Replication-deficient viruses provide an attractive alternative to conventional approaches used in the induction of antiviral immunity. We have quantitatively evaluated both the primary and memory cytotoxic T-lymphocyte (CTL) responses elicited by immunization with a replication-deficient mutant of herpes simplex virus type 1 (HSV-1). In addition, we have examined the potential role of these CT...

2014
Robert Carlsson Shohreh Issazadeh-Navikas

The PD-L1 protein has an extracellular domain, a transmembrane domain and an intracellular domain. The extracellular domain (ECD) of the PD-L1 protein is comprised of IgC–like and IgV-like domains [2]. The ECD of PD-L1 interacts with the programmed death 1 (PD-1, also known as PDCD1) and B7.1 receptors. Blocking of the PD-L1 molecule with antibodies blocks cancer cells from killing cytotoxic T ...

2016
Shaun R. Stipp Abdon Iniguez Frederic Wan Dominik Wodarz

CD8 T cell or cytotoxic T lymphocyte (CTL) responses are an important branch of the immune system in the fight against viral infections. The dynamics of anti-viral CTL responses have been characterized in some detail, both experimentally and with mathematical models. An interesting experimental observation concerns the timing of CTL responses. A recent study reported that in pneumonia virus of ...

Journal: :Investigative ophthalmology & visual science 1995
C K Joo J S Pepose P M Stuart

PURPOSE To evaluate the role that delayed-type hypersensitivity (DTH) and cytotoxic T lymphocyte responses play in a murine model of orthotopic corneal allograft transplantation. METHODS Corneal transplantation was performed by grafting C57BL/6 donor corneas into BALB/c corneal beds. After transplantation, the mice were observed by slit lamp biomicroscopy on a weekly basis and graded for sign...

2011
Barbara Molon Stefano Ugel Federica Del Pozzo Cristiana Soldani Serena Zilio Debora Avella Antonella De Palma PierLuigi Mauri Ana Monegal Maria Rescigno Benedetta Savino Piergiuseppe Colombo Nives Jonjic Sanja Pecanic Loretta Lazzarato Roberta Fruttero Alberto Gasco Vincenzo Bronte Antonella Viola

Tumor-promoted constraints negatively affect cytotoxic T lymphocyte (CTL) trafficking to the tumor core and, as a result, inhibit tumor killing. The production of reactive nitrogen species (RNS) within the tumor microenvironment has been reported in mouse and human cancers. We describe a novel RNS-dependent posttranslational modification of chemokines that has a profound impact on leukocyte rec...

2014
Jashodeep Datta Shuwen Xu Julia H Terhune Cinthia Rosemblit Erik Berk Elizabeth Fitzpatrick Brian J Czerniecki

Background Although cytotoxic CD8 T lymphocytes (CTL) were historically considered primary effectors of antitumor immunity, solely boosting CTL responses with CD8 vaccines in various tumor types has yielded unpredictable clinical results, possibly because CTLs function suboptimally without adequate CD4 T lymphocyte help. CD4 T-helper type 1 (Th1) cells secrete INF-g/TNF-a, inducing tumor senesc...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
A De Maria A Ferraris M Guastella S Pilia C Cantoni L Polero M C Mingari D Bassetti A S Fauci L Moretta

Human T lymphocytes have been shown to express inhibitory natural killer cell receptors (NKR), which can down-regulate T cell antigen receptor-mediated T cell function, including cytolytic activity. In the present study, we demonstrate that CD3+NKR+ cells can be identified in HIV-infected patients. HIV-specific cytolytic activity was analyzed in five patients in whom autologous lymphoblastoid B...

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