Cytotoxic T cells were detected in the cervical lymph nodes, lungs, spleen, and peripheral blood of mice with influenza. Lymphocytes decreased in the peripheral circulation and increased in the lung during the period of acute inflammation and pneumonia. Peak cytotoxic T-cell activity was present at the time of marked pulmonary infiltration, and it decreased with resolution of the pneumonia. The...

background: endodontic sealers usually come in contact with adjacent tissues and their biocompatibility is key in a successful treatment. the purpose of this study was to assess the cytotoxicity of three resin-based sealers, namely ah plus, endorez, and epiphany in set and fresh states on an l929 cell line. materials and methods: in this in vitro experimental study, the materials were mixed acc...

several attempts have so far been made in the search of new anticancer agents of plant origin. some studies have reported that different species of pine genus possess cytotoxic activities against various cancer cell lines. in the present study, we evaluated the cytotoxic effects of pinus eldarica bark and leaf extracts or leaf essential oil on hela and mcf-7 tumor cell lines. hydroalcoholic and...

The studies reported herein were designed to determine the effects of allogeneic effect factor (AEF), a soluble mediator generated in the course of allogeneic cell interactions, on the differentiation of cytotoxic T lymphocytes in vitro. Normal, unprimed spleen cells from various strains of mice cultured with AEF for 5 days, in the absence of any stimulator cells, developed into cytotoxic lymph...

The cytotoxic potential of stem organic extracts from Calotropis procera (Asclepiadaceae) was firstly evaluated against cancer cell lines by MTT assay. Subsequently, samples considered cytotoxic were tested for antimitotic activity on sea urchin egg development and for in vivo antiproliferative activity in mice bearing Sarcoma 180 tumor. Among the five extracts (hexane, dichloromethane, ethyl a...

Specific cytotoxic thymus-derived (T) lymphocytes were detected in the cervical lymph nodes and spleen during influenza infection of mice. The cytotoxic T cells can distinguish target cells infected with different influenza A subtypes. Infection with parent viruses and their recombinant progeny possessing the hemagglutinin of one parent and the neuraminidase of the other demonstrated that sign...

Background: Plants are a proven source of anti-tumor compounds and it is reasonable to assume that many such substances remain to be discovered. In Iranian folk medicine, ethanolic extract of the aerial parts of Daphne mucronata Royle is used against various skin disorders.Objective: In order to evaluate anti-neoplastic plants, we initiated a cytotoxic study using Daphne mucronata that is indig...

A series of 2-amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) as a catalyst at room temperature. Mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. The cytotoxic activity of target compounds were evaluated against t...