There are at least two basal cell populations in the olfactory epithelium that could give rise to olfactory neurons during development, in the normal adult, and after experimentally induced receptor cell death. These populations have been subdivided as horizontal (HBC) and globose (GBC) basal cells on the basis of morphological criteria and by staining with antibodies against cytokeratin. HBCs ...

BACKGROUND AND OBJECTIVES The aim of this study is to determine whether the hyperproliferative and hyperkeratotic characters of cholesteatoma are associated with differentiation of keratinocytes in cholesteatoma by examining the localization of marker proteins, such as involucrin, filaggrin, and cytokeratins. MATERIALS AND METHODS Immunohistochemical study was carried out in 30 cholesteatoma ...

Colorectal cancer (CRC) is the second most prevalent cause of cancer-related deaths in the Western world. 5-Fluorouracil (5-FU) is a standard chemotherapeutic drug to treat CRC. However, the response rate is less than 20% and patients who have responded to 5-FU may become resistant. Therefore there is an urgent need to examine the 5-FU response proteins so that patients with no response to 5-FU...

Objective: To evaluate the diagnostic efficacy of cytokeratin 19 for presence and spread oral squamous cell carcinoma following incisional biopsy. Study Design: Descriptive Cross-sectional. Setting: Isra Dental College Hospital, University Hyderabad. Period: November 2020 to October 2021. Material & Methods: Consenting patients either gender, age 20-70 years, with clinical suspicion OSCC we...

Abstract Background Cytokeratin 18 (CK18) is an intermediate filament protein of the cytokeratin acidic type I group and primarily expressed in single-layered or “simple” epithelial tissues carcinomas different origin. Methods To systematically determine CK18 expression normal cancerous tissues, 11,952 tumor samples from 115 types subtypes (including carcinomas, mesenchymal biphasic tumors) as ...

BACKGROUND Alopecia is one of the most important hair follicle (HF) disorders, which is divided into scarring (cicatricial) and nonscarring (noncicatricial) types. OBJECTIVE The aim of this study is to investigate the expression of stem cell (SC) markers such as cytokeratin (CK) 17 and CK19 in scarring and nonscarring alopecia. MATERIALS AND METHODS Thirty patients with scalp alopecia (15 w...

AIM OF THE STUDY This work aims to search for markers suitable for the screening of bladder cancer, which should be specific, sensitive, reproducible, non-invasive and at acceptable cost. PATIENTS AND METHODS The study included 50 patients diagnosed as bladder cancer (35 TCC, 15 SCC) of different stages and grades, 30 patients with various urothelial diseases, besides 20 apparently healthy su...

The pancreatic ductal adenocarcinoma (PDAC), which represents over 90% of cancer cases, has the highest proliferative and metastatic rate in comparison to other compartments. This study is designed determine whether small nucleolar RNA, H/ACA box 64 (snoRNA64) associated with initiation progression. Gene expression data from Expression Omnibus (GEO) repository have shown that snoRNA64 reduced p...

Objective: The To distinguish between basal and non-basal subtypes of triple-negative breast cancers based on epidermal growth factor receptor cytokeratin 5/6, to establish the association diagnosis with clinicopathological parameters survival rates.Methods: retrospective study was conducted at Clinical Oncology Nuclear Medicine Department Kafrelsheikh University Hospital Tanta Hospital, Egypt,...