Study of AgNOR has been identified as a reliable indicator of cell proliferation and in turn, allows a clear distinction between benign, premalignant, and malignant epithelial changes. The aim of this study was to analyze and evaluate the application of AgNOR method as diagnostic tool in non-neoplastic and neoplastic lesions of endometrium. The study included evaluation of AgNOR staining on a t...

Endometrial cancer is the most common gynecological cancer in Western industrialized countries. Cables, a cyclin-dependent kinase binding protein, plays a role in proliferation and/or differentiation. Cables mutant mice are viable, but develop endometrial hyperplasia and carcinoma in situ at a young age. Exposure to chronic low levels of estrogen results in development of endometrial cancer, si...

BACKGROUND AUB is a common cause of women's referring to gynecologists. Although hysteroscopy is known as the gold standard technique for diagnosing the cause of AUB, sonohysterography is less invasive, and it is performed by general gynecologists. The purpose of this study was to evaluate the diagnostic performance of sonohysterography compared to the results of the endometrial biopsy, guided ...

OBJECTIVE This study was undertaken to evaluate whether it was possible to abstain from performing an endometrial biopsy when endometrial thickness according to transvaginal ultrasonography was /=50 years who were re...

Aim: Abnormal uterine bleeding refers to any uterine bleeding that occurs in excessive amounts of regular menstrual bleeding or any postmenopausal bleeding. The present study aims to determine histopathological findings in Turkish women with abnormal uterine bleeding in Elazığ. Material and Methods: Retrospectively 420 women with abnormal uterine bleeding were included in the study. Hematoxylin...

Introduction: Endometrial hyperplastic processes (EHP) are characterized by recurrent course, high risk of malignancy, difficulties in diagnosing and predicting the which determines their great medical social significance
 Objective: To evaluate levels proliferation markers Ki-67 APRIL serum women with various forms endometrial correlation clinical anamnestic features.
 Materials Meth...

Ovarian granulosa cell tumors represent uncommon neoplasms with estrogen-secreting capacity. Due to their association with persistently increased levels of estrogen, modifications of the endometrial tissue ranging from hyperplasia to malignant degeneration may be encountered. We present the case of a 65-year-old patient who presented for post-menopausal vaginal bleeding. The endometrial biopsy ...

OBJECTIVE To determine the prevalence of pathologic changes in the endometrium of tamoxifen-treated asymptomatic postmenopausal patients with breast cancer. SUBJECTS AND METHODS Fifty postmenopausal asymptomatic breast cancer patients with positive estrogen receptor status were treated with 20 mg of tamoxifen daily for a period of 5-60 months. The control group consisted of 30 asymptomatic po...

BACKGROUND Abnormal uterine bleeding is a common presentation of uterine abnormalities among premenopausal and postmenopausal women. OBJECTIVE To evaluate and compare the diagnostic accuracy of saline contrast sonohysterography and hysteroscopy for detecting the cause of abnormal uterine bleeding. MATERIALS AND METHODS A total of 65 women with abnormal uterine bleeding were enrolled in this...

OBJECTIVE To determine agreement of preoperative and postoperative histopathology of endometrial hyperplasia (EH). MATERIALS AND METHODS Histopathology of specimens obtained by curettage and hysterectomy within 1 year was retrospectively compared by a skilled gynecological pathologist. Patients who received hormone therapy were excluded. RESULTS Of 79 women with a preoperative diagnosis of ...