cypa

The majority of the effects of cyclosporin A (CsA) on cells is caused by the inhibition of phosphatase activity of calcineurin (CN) by the cyclophilin A (CyPA)-CsA complex formed in the cytoplasm. Although CsA inhibits the proliferation of a large number of parasites, not all are susceptible. The presence of structurally altered CyPA with lower affinity for CsA had been suggested to be the caus...

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A Cyclophilin Homology Domain-Independent Role for Nup358 in HIV-1 Infection

2014

Anne M. Meehan Dyana T. Saenz Rebekah Guevera James H. Morrison Mary Peretz Hind J. Fadel Masakazu Hamada Jan van Deursen Eric M. Poeschla

The large nucleoporin Nup358/RanBP2 forms eight filaments that project from the nuclear pore into the cytoplasm where they function as docking platforms for nucleocytoplasmic transport receptors. RNAi screens have implicated Nup358 in the HIV-1 life cycle. The 164 C-terminal amino acids of this 3,224 amino acid protein are a cyclophilin homology domain (Nup358Cyp), which has potential to bind t...

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Positive Correlation between Activated CypA/CD147 Signaling and MMP-9 Expression in Mice Inflammatory Periapical Lesion

Journal: :BioMed Research International 2019

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Keep on Moving: Discovering and Perturbing the Conformational Dynamics of Enzymes

2015

Gira Bhabha Justin T. Biel James S. Fraser

CONSPECTUS: Because living organisms are in constant motion, the word "dynamics" can hold many meanings to biologists. Here we focus specifically on the conformational changes that occur in proteins and how studying these protein dynamics may provide insights into enzymatic catalysis. Advances in integrating techniques such as X-ray crystallography, nuclear magnetic resonance, and electron cryo...

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نمودار تعداد نتایج جستجو در هر سال

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