Despite availability of many antifungal agents, antifungal clinical resistance occurs, perhaps as a consequence of an infecting organism found to be resistant in vitro to one or more antifungals tested. From what derives the important current role of the in vitro antifungal susceptibility testing (AFST), that is to determine which agents are like to be scarcely effective for a given infection. ...

Sir, Triazole antifungals are the mainstay of therapy for patients with aspergillosis. Notably, the mortality associated with aspergillosis is high and the rate of treatment failure is much higher if patients are infected with multiple-triazole-resistant (MTR) Aspergillus fumigatus. MTR A. fumigatus strains with the mutation TR34/ L98H occur both in azole-treated as well as in azole-naive patie...

にば Invasive pulmonary aspergillosis (IPA) continues to rise in concert with increasing にぱ numbers of immune suppression techniques to treat other medical conditions and にひ transplantation. Despite these advances, morbidity and mortality remain unacceptably ぬど high. One strategy utilized to optimize outcomes is antifungal pharmacodynamic (PD) ぬな examination. We explored the pharmacodynamics of a...