a lot of researches have investigated the effects of topical cyclosporine a on the eye surface layers' diseases. by now the main limitation in cyclosporine application is the low permeation of the drug into the posterior segments of the eye. the aim of present study was to formulate high permeable dosage form can be beneficial in the topical treatment of the uveitis. to reach higher corneal dru...

BACKGROUND Thymectomy can effectively cure most thymoma patients; however, patients with advanced thymoma typically require chemotherapy, which is associated with limited efficacy in this context. Here we provide the first report of a patient with recurrent thymoma who achieved complete remission (CR) using cyclosporine therapy. CASE PRESENTATION A 63-year-old woman who had undergone resectio...

BACKGROUND Nephrotoxicity of calcineurin inhibitors (CNIs) is partially responsible for the development of chronic allograft nephropathy (CAN). Sirolimus has demonstrated its potential to substitute for CNIs because it lacks significant nephrotoxicity and shows a short-term immunosuppressive capacity comparable with that of cyclosporine. This results in the maintenance of better renal function ...

This review examines the relationship between renal transplantation and two important metabolic consequences: hyperlipidemia and glucose intolerance. Before cyclosporine, hypertriglyceridemia and hypercholesterolemia were common abnormalities that worsened in the cyclosporine era. In addition to obesity, steroid use, and reduced renal function, cyclosporine plays an independent role in elevatin...

Cross-correlation of cyclosporine concentrations with results of biochemical tests of renal and liver function, measured during the first three months post-operatively, was carried out retrospectively in 24 heart and eight heart-lung transplant recipients to assess the temporal relationship between cyclosporine treatment and the development of possible toxic side-effects. We found a statistical...

One hundred seventy-nine patients with acute nonlymphoblastic leukemia in first remission (n = 75), chronic myelocytic leukemia in chronic or accelerated phase (n = 48) or leukemia in advanced stage (n = 56) were given HLA-identical marrow grafts and randomized to receive methotrexate or cyclosporine for prevention of graft-v-host disease (GVHD). The current report updates the three prospective...

The recent report from the Southwest Oncology Group by List et al1 regarding the benefit of cyclosporine modulation of Pglycoprotein drug resistance in poor-risk acute myeloid leukemia (AML) was read with anticipation, as optimal regimens for this difficult patient population have remained elusive. Upon reviewing the paper, however, several concerns became apparent. The use of one-sided analysi...

Sir, We read with great interest the article by Ralf Westenfeld et al. [1] regarding the reduced serum levels of bone resorption markers (TRAP-5b and sRANKL) in patients treated with sirolimus (SRL) after renal transplantation compared to a calcineurin inhibitor (CI)-based regimen, and in vitro, SRL reduced osteoclast differentiation and osteoclast precursor proliferation. So the authors conclu...