objective(s) there are some reports that the teratogenic effects of cyclophosphamide (cpa) can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. echinacea purpurea extract is antioxidative and immunomodulator drug. mesna (sodium 2-mercaptoethane sulfonate) is used for decreasing side effects of cpa, especially hemorrhagic cystitis. in this study, we...

background: gallic acid (ga) is an endogenous plant phenol known to have antioxidant, free radical scavenging ability, anti‑inflammatory, anti‑cancer, and anti‑fungal properties. the aim of this study was to assess the protective effect of ga on cyclophosphamide (cpa)‑induced hepatotoxicity in male wistar rats. methods: sixty rats were grouped into six groups of 10 rats per group. group 1 recei...

Kim S, Choi HJ, Jo CH, Park JS, Kwon TH, Kim GH. Cyclophosphamide-induced vasopressin-independent activation of aquaporin-2 in the rat kidney. Am J Physiol Renal Physiol 309: F474–F483, 2015. First published June 24, 2015; doi:10.1152/ajprenal.00477.2014.—Because cyclophosphamide-induced hyponatremia was reported to occur without changes in plasma vasopressin in a patient with central diabetes ...

Nausea and vomiting are the most frequent painful adverse event of chemotherapy. Uncontrolled nausea lead to a significant decrease in quality life patients, nutritional insufficiency, breaking chemotherapy therapy regimen. worsen result prognosis disease. In clinical studies antiemetic drugs “complete response” is used as primary endpoint. The complete redponse absence need for additional drug...

We report the case of a patient with multiple myeloma who developed acute life-threatening water intoxication following treatment with oral indomethacin and low dose intravenous cyclophosphamide. We describe a possible drug interaction between these two drugs and recommend that they should only be used together with caution.

 ABSTRACT Background: The prognosis of SLE is int1uenced by the onset of glomerulonephtitis. Clinical ttials in lupus nephritis have demonstrated that cyclophosphamide therapy is the superior regimen in the management oflupus nephritis for preserving renal function. Objective: The purpose of this study is to define the outcome of renal function with bolus pu lses of cyclophosphamide and steroid...

Objective: The use of multiple medications in cancer patients is unavoidable; thus, adverse drug-drug interactions are frequent. This study aims to assess the prevalence potential drug oncology visiting outpatient chemotherapy unit.
 Method: Demographic and health-related information an unit was recorded using a pre-prepared form. A comprehensive list all concurrently used compiled checked...

OBJECTIVE Systemic lupus erythematosus (SLE) disproportionately affects women and often develops during their reproductive years. Research suggests that some women who receive cyclophosphamide as treatment for SLE experience earlier decline in menstrual function, but reproductive health among women with SLE who have not taken this drug is less well understood. This study aims to better understa...

1. dept. of hematology, oncology, kermanshah university of medical sciences, kermanshah, iran 2. medical biology research center, kermanshah university of medical sciences, kermanshah, iran 3. students research committee, kermanshah university of medical sciences, kermanshah, iran     corresponding author: masoud sadeghi, msc; degree in biochemistry tel: (+91) 8338428221 email: sadeghi_mbrc@yah...