The natural UV-screener scytonemin is found in a plethora of cyanobacterial species. Its UVprotective ability allows the bacteria to thrive in inhospitable locations exposed to intense solar radiation. Scytonemin has a dimeric structure consisting of two 1-1' linked 3-(4hydroxybenzylidene)cyclopenta[b]indole-2-one moieties. The cyanobacterial pigment nostodione A consists of the same skeleton, ...

The use of biomass-derived compounds as substitutes of pet roleum has received much a t tent ion1)~4). Because of the complex nature of biomass, the conversions of biomass to chemicals usually start with the production of small molecules called platform chemicals by thermal, chemical or biological processing5). Among these platform chemicals, furfural6) and 5hydroxymethylfurfural (HMF)7) are es...

This account outlines the results obtained in the author’s laboratory on the application of phosphonate reagents in the synthesis of biologically active cyclopentanones and cyclopentenones. The synthesis and reactivity of 3-phosphorylmethyl-cycloalkenones is discussed as a platform for developing the first synthesis of enantiomeric isoterreins as well as the synthesis of racemic and optically a...

This article reviews our contribution in the field of radical synthetic chemistry, focusing on cascades relying on the use of propargylic BMDMS ethers and asymmetric synthesis using enantiopure vinylsulfoxides. THE 5-EXO-DIG CYCLIZATION OF BMDMS PROPARGYLIC ETHERS: AN EFFICIENT TRIGGER FOR RADICAL CASCADES The vinyl radical, a precious tool The vinyl radical of type 3 resulting from the highly ...

Thc intraperitoneal administration or I -aminocyclopentane carboxylic acid, I -aminocyelohexane carhoxylic acid. I-aminocycloheptane carboxylic acid. I-aminocyclooctane carboxylic acid, uxo-2aminohicyclo(2.2. I )heptdne-2-carboxylic acid. enrlo-2-aminobicyclo( 2.21 )heptane-2-carboxylic acid. 2aminohicyclo(2.2.2~octane-2-earboxylic acid and 2-aminobicyclo(3.2. I )octane-2qrboxylic acid to I8-da...

Monofluoroalkenes are fluorinated motifs that can be used to replace amide bonds. In order to be incorporated into peptides, it is normally necessary to first synthesize a dipeptide where the amide bond has been replaced with a monofluoroalkene. In that context, this review will present the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres described since 2007...

Mental visualization of diagrammatic representations is presumed to be a critical strategy for learning and problem solving, particularly in the sciences. However, little is known about how students employ visualization on genuine scientific tasks. The present study describes undergraduate chemistry students’ use of visualization for problem solving using think-aloud protocols. The analysis sug...

Accurate solvation parameters have been established using solely gas/liquid partition data by gas/chromatography from the Kováts group (Laffort et al. J. Chromatog. A, 2005, 1100, 90-107). Because these chromatographic data have been recently updated (Kováts and Kresz, J. Chromatog. A, 2006, 1113, 206-219), the solvation parameters of the involved solutes and stationary phases have been entirel...