Prostate tumor cell targeted peptide fragment conjugated to the nano drug delivery system is a promising strategy for prostate cancer therapy. In this work, an amphiphilic copolymer Chol-PEG-DUP1 (PEG-cholesterol conjugated with DUP1 peptide) has been synthesized and characterized by proton nuclear magnetic resonance spectrum ((1)H NMR). The paclitaxel (PTX) was encapsulated into the Chol-PEG-D...

Background: Neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s Multiple Sclerosis, Dementia, and others are becoming more common globally due to people’s changing lifestyles. Furthermore, the presence of Blood-Brain barrier other limitations oral routes administration makes drug delivery brain somewhat tricky. As a result, numerous novel systems being developed for brain. Howe...

nanotechnology has changed our lives dramatically and influenced every sector of the research, engineering and also business community. nanotechnology is a rapidly growing science of producing and utilizing nano-sized particles, that measure in nanometer. in other words, nanotechnology is the art of characterizing, manipulating and organizing matter systemically, at the nanometer scale, which h...

BACKGROUND Nano bamboo charcoal is being widely used as sustained release carrier for chemicals for its high specific surface area, sound biocompatibility, and nontoxicity; however, there have been no reports on nano bamboo charcoal as sustained release carrier for traditional Chinese medicine (TCM). OBJECTIVE To study the effect of nano bamboo charcoal in absorbing and sustained releasing Eu...

Research on colon-targeted polymers delivery systems is ongoing for conditions such ulcerative colitis, Crohn's disease, colon cancer, as well the of peptide or protein medications and vaccines. For colon-specific disorders in particular, focused nano-drug to helpful because nanoparticles can build up sick areas, improve therapeutic efficacies, allow localized therapies, which lower systemic to...

background :wide distribution and low half-life of acyclovir has led to a high dose consumption of the drug. recent studies have shown that encapsulation of acyclovir in nano-carriers can increase effectiveness and decrease its side effects. we investigated the inhibitory effect of acyclovir loaded nano-niosomes against herpes simplex virus type-1 (hsv-1) in cell culture.   methods : in-vitro c...

Nanotechnology (nano-materials and nano-process) has been developed for both industrial and medical applications. The use of nano-medicine has been used in bio-imaging and bio-sensing, drug delivery, cancer cell diagnostics and therapeutics [1,2]. Nanoparticles (NPs) can cause tumor cell death by photothermal ablation, photodynamic toxicity, mechanical damage, or increase in the localized drug ...

Due to uniquely ordered nanoporous structure and high surface area as well as large pore volume, mesoporous materials have exhibited excellent performance in both controlled drug delivery with sustained release profiles and formulation of poorly aqueoussoluble drugs with enhanced bioavailability. Compared with other bulk excipients, mesoporous materials could achieve a higher loading of active ...

In the deca-hydro-phenanthrenone ring system of the title compound, C(27)H(44)O, the two cyclo-hexane rings adopt chair conformations, whereas the cyclo-hexene ring adopts an envelope conformation. The cyclo-pentane ring is twisted. In the crystal structure, mol-ecules are stacked along the a axis, but no significant inter-molecular inter-actions are observed.

Research in the areas of drug delivery and tissue engineering has witnessed tremendous progress in recent years due to their unlimited potential to improve human health. Meanwhile, the development of nanotechnology provides opportunities to characterize, manipulate and organize matter systematically at the nanometer scale. Biomaterials with nano-scale organizations have been used as controlled ...