Cyclic Vomiting Syndrome (CVS) has been linked to episodic migraine, yet little is known about the precise brain-based mechanisms underpinning CVS, and whether these associated conditions share similar pathophysiology. We investigated the functional integrity of salience (SLN) and sensorimotor (SMN) intrinsic connectivity networks in CVS, migraine and healthy controls using brain functional Mag...

BACKGROUND: Functional gastrointestinal disorders; i.e., irritable bowel syndrome, cyclic vomiting, gastro-esophageal reflux and dyspepsia, are more common in individuals with migraine. Autonomic manifestations of migraine, and less commonly of paroxysmal hemicranias (PH), include those of gastrointestinal (GI) tract origin. METHODS: Repeated cl inical neurological examinations, long term follo...

INTRODUCTION Domperidone is a dopamine receptor antagonist with peripheral prokinetic and central antiemetic properties. Prolongation of the QTc interval with chronic use of oral domperidone in standard doses has been reported in the literature. Our goal was to investigate cardiac toxicity in patients receiving 2-fold greater doses than in previous reports. METHODS A retrospective chart revie...

Ramsay-Hunt Syndrome (Herpes zoster oticus) is often characterized by severe ear pain, vesicles on external auditory canal or auricula and peripheral facial paralysis. However, the patient in this case presented to clinic with dizziness, pain vomiting. During physical examination there was no evidence of skin changes found around that were typical for Ramsay Hunt syndrome. The did not have If a...

This review reports main progresses in various pediatric issues published in Italian Journal of Pediatrics and in international journals in 2016. New insights in clinical features or complications of several disorders may be useful for our better understanding. They comprise severe asthma, changing features of lupus erythematosus from birth to adolescence, celiac disease, functional gastrointes...

Transmural perforation of the esophagus following an effortful vomiting is a rare but fatal condition. This situation, known as Boerhaave’s syndrome, is caused by spontaneously occurring perforations. The esophagus is not resistant to reflexes such as nausea and vomiting because it lacks serosal layers. Boerhaave syndrome, in which substantial amounts of spontaneous perforations occur, is gener...

CASE Denise is a 10-year-old girl who was admitted to the hospital for treatment of dehydration secondary to severe vomiting for 2 days. She was unable to retain any liquids. This was her 62nd admission for similar symptoms. These began when she was 5 years old. There was no family history of relatives with similar symptoms, but a paternal grandmother had severe migraine episodes for much of he...