Antiplatelet therapy with clopidogrel is widely used as a preventive strategy in patients with acute coronary syndrome, particularly after stent implantation. Diverse manifestations of clopidogrel hypersensitivity reaction have been reported including cutaneous, and hematologic symptoms as well as fatal reactions including thrombotic thrombocytopenic purpura (TTP). Clopidogrel cutaneous hyperse...

Background According to recent studies cutaneous manifestations to non-steroidal anti-inflammatory drugs (NSAID) may affect 0.3% of general population and the prevalence of aspirin hypersensitivity is as high as 27-35% in patients with chronic urticaria (CU). NSAID may be the cause of acute urticaria but in CU patients it usually exacerbates the disease by inhibition of the cyclooxygenase, whic...

Q&A: Food additive intolerance 1) What is food additive intolerance and can you tell us what the most common symptoms are? Food additive intolerance is a non-IgE mediated food hypersensitivity. The hypersensitivity is induced by the food additives via a direct mast cell activation. Although the exact pathophysiology is unknown, various clinical signs are characteristic of food additive intolera...

Feline allergic skin disease presents a unique set of challenges to the veterinary practitioner. Although there is some similarity to what is seen in the allergic canine patient, cutaneous hypersensitivity dermatoses in cats can manifest with strikingly different clinical signs, treatment options and outcomes, and secondary complications/disease entities. Additionally, less is known about the p...

BACKGROUND Hypersensitivity reactions against nonsteroidal antiinflammatory drugs (NSAIDs) like diclofenac (DF) can manifest as Type I-like allergic reactions including systemic anaphylaxis. However, except for isolated case studies experimental evidence for an IgE-mediated pathomechanism of DF hypersensitivity is lacking. In this study we aimed to investigate the possible involvement of drug- ...

BACKGROUND Pyrazolones are the most common causes of selective nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity. We studied a large group of patients with immediate and delayed selective responses to metamizole. METHODS Patients with suspicion of hypersensitivity to metamizole were evaluated. We verified acetylsalicylic acid tolerance and classified patients as immediate or delaye...

Eslicarbazepine acetate (ESL) is an anticonvulsant drug approved for the treatment of focal epilepsies, and related to oxcarbazepine and carbamazepine (CBZ), which are also derivatives of the dibenzazepine family. ESL is contraindicated in patients with hypersensitivity reactions to CBZ.We report a patient with frontal lobe epilepsy responding to treatment with ESL without any serious adverse e...

Anticonvulsant hypersensitivity syndrome is a systemic illness that presents most commonly as a triad of fever, rash, and lymphadenopathy in a patient exposed to one or more of the aromatic antiepileptic drugs (phenytoin, phenobarbital, and carbamazepine). Although generally self-limited, the syndrome may be life-threatening, particularly among patients who develop severe cutaneous eruptions or...

1. Rabbits were rendered very hypersensitive by relatively small doses of green streptococci given intracutaneously, and somewhat less hypersensitive by similar doses of heat-killed vaccine prepared from hemolytic streptococci. 2. Animals receiving the same doses intravenously gave, upon subsequent testing, lesions slightly more marked than normal controls; but these lesions were qualitatively ...

Pharmacologic hypersensitivities commonly express cutaneous manifestations, and the highest mortality is found in Stevens Johnson’s syndrome and toxic epidermal necrolysis, mostly associated with antibiotics and anticonvulsive drugs. Toxic epidermal necrolysis is related in 80% of cases to pharmacologic hypersensitivity and systemic consequences may be found; hepatic injury has been described, ...