Current therapy for Hodgkin disease is aimed at high cure rates and optimal survivorship. Although intensified chemotherapy with the escalated BEACOPP regimen resulted in higher rates of cure and survival compared with COPP/ABVD in the high-profile HD9 randomized controlled trial (RCT), this regimen has not been universally adopted by patients and physicians due to the attendant increased risks...

Liver failure and liver diseases are major health problems worldwide leading to high mortality and also one of the high healthcare costs. Millions of patients die due to liver pathologies and liver diseases every year throughout the world. Use of stem cells to cure liver diseases has been proved beneficial in most of the conditions. Scientific literature reveals the role of stem cells in treatm...

Tuberculosis remains a public health problem in Brazil. In 2003, controlling tuberculosis was highlighted as a priority among health public policies. The article reports the Brazilian response to this challenge, describing the main strategies of the National Control Plan for 2003 to 2006. Among its main results are: expansion of strategic coverage of the supervised treatment, increase in the pe...

MO XF, FAN DB, QIN TF & CHU FX. 2015. Curing characteristics and adhesion performance of phenol–formaldehyde resins with composite additives. The curing characteristics of cure-accelerated phenol–formaldehyde resins with composite additives were investigated by differential scanning calorimetry analysis and gelation test. The pot lives and adhesion performances of phenol–formaldehyde resins wer...

In order to investigate the incidence, clinical and microbiologic characteristics of Clostridium difficile infection (CDI) in Korea, a prospective observational study was performed. From September 2008 through January 2010, all patients whose stool was tested for toxin assay A&B and/or C. difficile culture were studied for clinical characteristics. Toxin types of the isolates from stool were te...

Patient data from eight clinical trials were pooled and analyzed to study the efficacy and safety of the six-dose versus four-dose regimen of artemether-lumefantrine (coartemether; Coartem) in children weighing 5-25 kg. A total of 544 patients with uncomplicated P. falciparum malaria (six-dose: 343; four-dose: 201), matched for demographic and baseline characteristics and individual coartemethe...

Sustained-releasing praziquantel (SRP) tablet was designed for single dose treatment regimen of clonorchiasis. A previous pre-clinical study confirmed its sustained-releasing characteristics and a better cure rate than conventional praziquantel (PZQ). In this clinical study, the pharmacokinetics of this SRP tablet were investigated in human volunteers (phase 1; 12 volunteers), and its curative ...

One of the top research priorities of the international AIDS society by the action "Towards an HIV Cure" is the purge or the decrease of the pool of all latently infected cells. This strategy is based on reactivation of latently reservoirs (the shock) followed by an intensifying combination antiretroviral therapy (cART) to kill them (the kill). The central nervous system (CNS) has potential lat...

The 2 Spanish groups, Grupo Español de MM (GEM) and Programa para el Estudio de la Terapéutica en Hemopatía Maligna (PETHEMA), report on the superiority of both event-free survival (EFS) and overall survival (OS) in patients in whom complete response (CR) status was achieved, compared with lesser response categories (near-CR [nCR], very good partial response [VGPR], partial response [PR]), in a...