Over the past several years, the cancer risks associated with radiation from diagnostic imaging have received increased attention in both the medical literature and the lay press. In the midst of this heightened scrutiny, there has been growing support for the idea of tracking cumulative dose estimates that longitudinally document the accumulated medical radiation exposure of each individual pa...

Sanding joint compounds is a dusty activity and exposures are not well characterized. Until the mid 1970s, asbestos-containing joint compounds were used by some people such that sanding could emit dust and asbestos fibers. We estimated the distribution of 8-h TWA concentrations and cumulative exposures to respirable dusts and chrysotile asbestos fibers for four worker groups: (1) drywall specia...

BACKGROUND The objectives of this study were to determine whether cross-shift changes in peak expiratory flow rate (PEFR) were related to respirable dust exposure in South African coalminers. METHODS Fifty workers were randomly selected from a cohort of 684 miners from 3 bituminous coalmines in Mpumalanga, South Africa. Peak expiratory efforts were measured prior to the commencement of the sh...

OBJECTIVE To investigate the potential effects of lifetime cumulative ozone (O3) exposure on acute pulmonary responses to O3. METHODS Fifteen healthy subjects from a larger cohort of young adults were exposed to 200 ppb O3 for 4 hours followed by bronchoscopy and bronchoalveolar lavage 18 hours later. Lung function, symptom questionnaires, and blood samples were obtained before and after each...

Coal miners have been shown to be at increased risk of developing chronic obstructive pulmonary diseases including emphysema. The objective of this study was to determine whether lifetime cumulative exposure to respirable coal mine dust is a significant predictor of developing emphysema at a clinically-relevant level of severity by the end of life, after controlling for cigarette smoking and ot...

In this paper we estimate the incubation period of a possible pathology following exposure to dioxins during poor diet. The tools developed for purpose include probabilistic extremal model and stochastic behavior distribution tails contamination. We propose cumulative function random variable that follows both Gaussian GPD. A global optimization method is also explored efficient estimation para...