Two cumulative damage models are considered, the inverse gamma process and a composed gamma process. They can be seen as ‘continuous’ analogues of Poisson and compound Poisson processes, respectively. For these models the first passage time distribution functions are derived. Inhomogeneous versions of these processes lead to models closely related to the Weibull failure model. All models show i...

Mathematical analysis of morphometric studies on the destruction of pulmonary tissue in cases of centrilobular emphysema has been used to identify degrees and localization of structural damage. From the data, an hypothesis of sequential, cumulative, individual destructive events has been developed to explain the distributive and progressive parenchymal changes in the lungs.

Occupational exposure to active pharmaceutical ingredients can cause adverse health effects, particularly in personnel working with potent compounds such as steroids or those with the capacity to cause cumulative damage, such as antineoplastic drugs and antibiotics (1). Although omeprazole and other proton pump inhibitors are potentially sensitizing, occupationally acquired cases are rare (2, 3...

Cumulative, repetitive microtrauma can cause tissue damage that leads to overuse injuries, which constitute a large share of sports-related disorders. The authors explain their five-step approach to treating overuse injuries: establishing a pathoanatomic diagnosis, controlling inflammation, promoting healing, increasing fitness, and controlling tissue abuse. The case of a 28-year-old male runne...

Introduction The effectiveness of anthracycline chemotherapy is limited by dose dependant cardiotoxicity. Current protocols reduce the cumulative dose, however subclinical myocardial damage may still manifest years after cessation of therapy. The most serious side effect is dilated cardiomyopathy with pathological changes of fibrosis. The potential presence of fibrosis in this remodelling is un...

This article examines the prospects for cost reductions of flat panel photovoltaic (PV) electricity. Current PV production cost ranges are presented, in terms of cost per peak W and cost per kWh, for single crystalline and multi-crystalline silicon, as well as for thin-film technologies. Possible decreases of these costs are assessed, as expected based on learning curves. The cumulative product...

Low cycle fatigue life of Ti and alloys decreases due to tensile stress dwell even at ambient temperature. This phenomenon is called Cold Dwell Fatigue (CDF). CDF properties are affected by time, test stress, microstructure. In our previous study, the effects time assessment linear cumulative damage rule were reported. The microstructure for discussed in this study. Test was from 0.85 0.955 σ0....

involve medical issues, and there are many traps for the unwary, particularly when the quality of the medical care is at issue. Virtually without exception, any injury case with substantial damages will become entangled with medical issues. There will always be issues of how to maximize the economic damages, usually dependent on numerous, sophisticated medical analyses. If medical malfeasance i...

One hundred and five cases of airgun pellet injuries of the eye have been analysed. The average age was 14 and the male to female ratio 7.5:1. Forty-five patients had final visual acuities of 6/18 or less in the injured eye and 19 of these had the eye removed. The two main causes for poor vision were retinal damage and cataract. One patient became completely blind after sympathetic ophthalmitis...