Abstract Background Enoxaparin 0.75 mg/kg, with either a staged-dose regimen (0.5+0.25 mg/dl) or single-dose (0.75 achieves target anticoagulation for 90 min in patients undergoing percutaneous coronary intervention (PCI). In prolonged procedures (>90 min), supplementary-dose enoxaparin (0.375 mg/kg) needs to be given at maintain additional min. However, the actual anticoagulant profile ...

introduction the gamma knife system is designed solely for non-invasive treatment of brain disorders, and it benefits from stereotactic surgical techniques. dose calculations required in the system are performed by gammaplan code; in this code, brain tissue is considered uniform. in the present study, we evaluated the effect of gamma knife system on the obtained dose through simulating a real h...

Purpose: To determine the recommended phase II dose and evaluate the safety and toxicity profile and pharmacokinetic (PK) and pharmacodynamic (PD) effects of BNC105P, an inhibitor of tubulin polymerization that has vascular disrupting and antiproliferative effects. Experimental Design: BNC105P was administered as a 10-minute infusion on days 1 and 8 of a 21-day cycle in a first-in-human phase I...

BACKGROUND In early-phase studies with targeted therapeutics and radiotherapy, it may be difficult to decide whether an adverse event should be considered a dose-limiting toxicity (DLT) of the investigational systemic agent, as acute normal tissue toxicity is frequently encountered with radiation alone. We have reanalyzed the toxicity data from a recently conducted phase 1 study on vorinostat, ...

a Department of physics, faculty of science, Takestan Branch, Islamic Azad University,Takestan, IRAN. b Engineering Department, Shahid Beheshti University, G.C., P.O. Box 1983963113, Tehran, IRAN. ________________________________________________________________________________________ Abstract: Absorption dose distribution of onion powder in electron irradiation system has been numerically inve...

The influence of electron beam lithography parameters (such as energy, resist thickness, the exposure dose) on sidewall shape (profile) was studied for PMMA (polymethyl-methacrylate) positive resist. profile tone investigated depending varying doses thicknesses 600 and 1300 nm, energy 30 keV. Simulation results based measurements along depth are presented discussed. obtained contribute to knowl...

PURPOSE Intensity modulated radiation therapy (IMRT) is a high precision therapy technique that can achieve a conformal dose distribution on a given target. However, organ motion induced by respiration can result in significant dosimetric error. Therefore, this study explores the dosimetric error that result from various patterns of respiration. MATERIALS AND METHODS Experiments were designed...

Purpose: Phase I clinical trials are generally conducted to identify themaximum tolerated dose (MTD) or the biologically active dose (BAD) using a traditional dose-escalation design. This designmaynot be applied to cancer vaccines, given their unique mechanism of action. The FDA recently published "Guidance for Industry: Clinical Considerations for Therapeutic Cancer Vaccines." However, many qu...

Monensin is a common feed additive used in various countries, where 1 of the associated benefits for use in beef cattle is improved efficiency of energy metabolism by the rumen bacteria, the animal, or both. Modeling fermentation-altering supplements is of interest, and thus, it is the purpose of this paper to quantify the change in VFA profile caused by monensin dose in high-grain-fed beef cat...