BACKGROUND Cerebral perfusion can be evaluated using a computed tomography (CT) scan by intravenous bolus injection of contrast media. The purpose of this study was to investigate the value of CT perfusion (CTP) in follow-up of extracranial-intracranial (EC-IC) bypass surgery. METHODS We retrospectively reviewed pre- and postoperative CTP studies in 14 patients who received EC-IC bypass surge...

Thermodynamic scaling explains the dramatic successes of CTP fused human growth proteins as regards lifetime in vivo and enhanced functionality compared to their wildtype analogues, like Biogen. The theory is semi-quantitative and contains no adjustable parameters. It shows how hydrophilic terminal spheres orient fused proteins in the neighborhood of a membrane surface, extending lifetimes and ...

OBJECTIVE To determine the level of association between minimal listing criteria (MLC) recognition and outcomes associated with waiting list registration for liver transplantation (LT). PATIENTS AND METHODS A total of 147 patients and 201 patients were identified as first-time referrals for LT evaluation between January 1, 1997, and November 30, 1997 (cohort A), and December 1,1997, and Decem...

We have used homology modeling to construct a three-dimensional model of the yeast mitochondrial citrate transport protein (CTP), based on the recently published x-ray crystal structure of another mitochondrial transport protein, the ADP/ATP carrier. Superposition of the backbone traces of the homology-modeled CTP onto the crystallographically determined ADP carrier structure indicates that the...

BACKGROUND AND PURPOSE The use of CT perfusion (CTP) imaging at a referring hospital is feasible and may shorten the door to puncture time for patients with acute ischemic stroke. METHODS We conducted a single center retrospective review of a prospectively maintained database of consecutive ischemic stroke patients transferred to our center for consideration of endovascular therapy. Patients ...

Throughout evolution, one of the most ancient forms of aggression between cells or organisms has been the production of proteins or peptides affecting the permeability of the target cell membrane. This class of virulence factors includes the largest family of bacterial toxins, the pore-forming toxins (PFTs). PFTs are bistable structures that can exist in a soluble and a transmembrane state. It ...

This paper presents and evaluates two principles for designing robust, reliable, and efficient collection protocols. These principles allow a protocol to benefit from accurate and agile link estimators by handling the dynamism such estimators introduce to routing tables. The first is datapath validation: a protocol can use data traffic as active topology probes, quickly discovering and fixing r...

Rationale and Objectives. Perfusion-weighted computed tomography (CTP) is a relatively recent innovation that estimates a value for cerebral blood flow (CBF) using a series of axial head CT images tracking the time course of a signal from an intravenous contrast bolus. Materials and Methods. CTP images were obtained using a standard imaging protocol and were analyzed using commercially availabl...

A single-step selection of Chinese hamster V79 cells deficient in CTP synthetase (CTPS-) is presented. The underlying principle of the direct selection is the differential and efficient killing of synchronized wild-type cells through incorporation of [3H]uridine and [3H]thymidine. The CTPS- mutant cells were recovered by virtue of their not engaging in DNA synthesis, because (1) CTPS- cells are...

BACKGROUND AND PURPOSE In CTP, an arterial input function is used for cerebral blood volume measurement. AIFs are often influenced by partial volume effects resulting in overestimated CBV. A venous output function is manually selected to correct for partial volume. This can introduce variability. Our goal was to develop a CTP protocol that enables AIF selection unaffected by partial volume. M...