نتایج جستجو برای: ct26
تعداد نتایج: 591 فیلتر نتایج به سال:
The synthesis and characterization of biotinylated chlorin photosensitizer and the corresponding zinc and indium complexes are described for potential applications in photodynamic therapy (PDT) for cancer. Phototoxicity of the biotin-chlorin conjugate and the metallated complexes was determined in colon carcinoma CT26 cell lines known to overexpress biotin (Vit B₇) receptors. Cell survival assa...
Abstract An antitumor abscopal effect is occasionally observed in radiotherapy and plasma treatment. It a remote induced by tumor irradiation that delays the growth of other distant, nonirradiated tumors. In this study, it was demonstrated normal tissues (not tumors) also leads to an effect. When pulsed streamer discharge irradiated left flanks mice where no existed, murine colorectal carcinoma...
Solubilized ~2sI-¢o conotoxin MVIIC receptors from rat cerebellum were immunoprecipitated by antibodies directed against the calcium channel ~ I A subunit. Anti-alA antibodies recognized a 240-220, 180 and 160 kDa proteins in immunoblots of cerebellar membranes. Disuccinimidyl suberate cross-linked ~2sI-~o conotoxin MVIIC to an ct26-1ike 200-180 kDa subunit, which migrated at 150-140 kDa after ...
The engineered Salmonella typhimurium ΔppGpp (S.t ΔppGpp) has been studied in terms of its ability to carry imaging probes (bacterial luciferase, Lux) for tumor imaging or carry therapeutic molecules (Cytolysin A) to kill cancer cells. To establish a novel cancer therapy, bacterial therapy was combined with radiotherapy using the attenuated strain S.t ΔppGpp/pBAD-ClyA. Radiotherapy (21Gy) contr...
Conquering immunosuppression in tumor microenvironments is crucial for effective cancer immunotherapy. It is well known that interleukin (IL)-6, a pleiotropic cytokine, is produced in the tumor-bearing state. In the present study, we investigated the precise effects of IL-6 on antitumor immunity and the subsequent tumorigenesis in tumor-bearing hosts. CT26 cells, a murine colon cancer cell line...
BACKGROUND Radiation therapy is the most widely used treatment for cancer, but it causes the side effect of mucositis due to intestinal damage. We examined the protective effect of genistein in tumor-bearing mice after abdominal irradiation by evaluation of apoptosis and intestinal morphological changes. METHODS Mouse colon cancer CT26 cells were subcutaneously injected at the flank of BALB/c...
Despite the impressive rates of clinical response to programmed death 1 (PD-1) blockade in multiple cancers, the majority of patients still fail to respond to this therapy. The CT26 tumor in mice showed similar heterogeneity, with most tumors unaffected by anti-PD-1. As in humans, response of CT26 to anti-PD-1 correlated with increased T- and B-cell infiltration and IFN expression. We show that...
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