Microalbuminuria is a marker of diabetic nephropathy and cardiovascular risk. Immunoassays underestimate the amount of intact albumin present in urine. The purpose of this study was to evaluate a new urinary albumin assay that uses size exclusion high-performance liquid chromatography (HPLC). We determined the limit of detection, linearity, imprecision, a comparison with an immunoturbidimetric ...

OBJECTIVE We aimed to detect C-reactive protein (CRP) in neonatal saliva and evaluate its diagnostic utility. STUDY DESIGN Salivary and serum samples (n = 89) were collected from 40 neonates. Salivary CRP levels were determined using an enzyme-linked immunosorbent assay; serum CRP was measured per hospital protocol. Correlation coefficients with 95% confidence intervals and robust linear regr...

since  clinical  manifestations  of  most  febrile  infants  younger  than  three  months  old  are nonspecific, differentiation of serious bacterial infection (sbi) from self-limiting viral illness is a significant challenge for pediatricians. this study was performed to assess the diagnostic value of white blood cell count (wbc), absolute neutrophil count (anc), interleukin -6 (il-6) and c-re...

BACKGROUND Cystatin C is a low molecular weight cysteine proteinase inhibitor whose plasma or serum concentrations have been shown to be better correlated with glomerular filtration rate than serum creatinine concentrations. Routine assays for cystatin C are based on use of polyclonal antibodies and immunoturbidimetric and nephelometric designs. This study aimed to develop a double-monoclonal i...

Abstract Background High sensitivity C-reactive protein (hs-CRP) is a biomarker used for risk prediction cardiovascular disease by assessing low concentration of inflammation. This study aims to assess the event-free time composite outcome between patients different hs-CRP groups and possible predictive value event occurrence in with chronic cardiac disease. Methods Data from 607 consecutive re...

Background: inflammation has been linked to cognitive impairment. However, limited data are available on the association between inflammatory markers and cognitive function. Objectives: we tested the hypothesis that elevated serum concentration of high sensitivity C-reactive protein (hs-CRP), an established marker of low-grade inflammation, predicts cognitive impairment in elderly women. Design...

  Background and Objective: Brucellosis is a main transmittable zoonotic disease, which is endemic, and a common health burden in Iran. Adenosine deaminase (ADA) is an essential enzyme which is involved in purine metabolism and its role in immune system is very important. The aim of this study was to determine serum changes of ADA and C-reactive protein (CRP) levels in patients with brucellosi...