Actomyosin-based cortical flow is a fundamental engine for cellular morphogenesis. Cortical flows are generated by cross-linked networks of actin filaments and myosin motors, in which active stress produced by motor activity is opposed by passive resistance to network deformation. Continuous flow requires local remodeling through crosslink unbinding and and/or filament disassembly. But how loca...

Directional microphones in hearing aids have been well-documented to improve speech recognition in noise in laboratory conditions. The real-world perceived benefits of directionality have been less dramatic. The development of directional technology during the past decade has focused on improving laboratory benefit by means of adaptive behavior, and more recently, binaural beamforming made poss...

DNA interstrand crosslinks (ICLs) are covalent linkages between two strands of DNA, and their presence interferes with essential metabolic processes such as transcription and replication. These lesions are extremely toxic, and their repair is essential for genome stability and cell survival. In this review, we will discuss how the removal of ICLs requires interplay between multiple genome maint...