Autophagy and apoptosis constitute important determinants of cell fate and engage in a complex interplay in both physiological and pathological settings. The molecular basis of this crosstalk is poorly understood and relies, in part, on "dual-function" proteins that operate in both processes. Here, we identify the essential autophagy protein Atg12 as a positive mediator of mitochondrial apoptos...

Regulation of Set1-COMPASS-mediated H3K4 methylation and Dot1-mediated H3K79 methylation by H2BK123 ubiquitination (H2Bub1) is an evolutionarily conserved trans-histone crosstalk mechanism. How H2Bub1 impacts chromatin structure and affects Set1-COMPASS/Dot1 functions has not been fully defined. Ubiquitin was proposed to bind proteins to physically bridge H2Bub1 with Set1-COMPASS/Dot1. Alternat...

In this paper, we address the problem of realtime detection of viruses docking to nanowires, especially when multiple viruses dock to the same nano-wire. The task becomes more complicated when there is an array of nanowires coated with different antibodies, where different viruses can dock to each coated nanowire at different binding strengths. We model the array response to a viral agent as a ...

Few tools exist to address the post-development activities of connguring, releasing, installing, updating, reconnguring, and even de-installing a software system. Certainly there is no uniied approach for all of these activities, and none that can take full advantage of a wide-area network. The Software Dock represents an architecture for supporting post-development activities in such a setting...

Abstract Cross-docking is a supply chain distribution and logistics strategy for which less-than-truckload shipments are consolidated into full-truckload shipments. Goods stored up to maximum of 24 hours in cross-docking terminal. In this chapter, we build on the literature review by Ladier Alpan (2016), who reviewed research conducted interviews with managers find gaps provide recommendations ...