Background: Differentiating oligodendrocyte precursor cells (OPCs) into oligodendrocytes could be improved by inhibiting signaling pathways such as Wnt and Notch. 9-cis-retinoic acid (9-cis-RA) and 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) can ameliorate oligodendrogenesis. We investigated whether they could increase oligodendrogenesis by inhibiting the Wnt and Notch signaling pathways.Methods: Co...

conclusions our study demonstrated that almost all ghq and msscq parameters were lower in ra patients, which indicates lower quality sexual life in ra patients. we recommend further consideration for the treatment and care of these patients. patients and methods in this case-control study, two groups of females (87 ra patients and 89 controls) were randomly selected from the rheumatology clinic...

conclusions our findings suggest that there is an association between the mthfr c677t polymorphism and susceptibility for the development of ra. results our results showed significant differences between the groups with respect to mthfr c677t genotype (p = 0.015) and allele frequencies (0.004). statistical analysis showed that there is no relation between gender, age, and ra risk. however, we fo...

Rheumatoid arthritis (RA) is a chronic disease, the etiology of which has yet to be clarified, which causes activation of proinflammatory pathways that bring about joint and systemic inflammation. In recent years, the pathophysiology of CNS involvement that can occur in RA has attracted a great deal of attention. Emphasis has focused on the possibility that CNS involvement occurs due to bl...

Address correspondence to: Pablo I. Altieri, MD, Cardiology Section, Department of Medicine, University of Puerto Rico Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-5067. Email: [email protected] Metabolic syndrome is a cluster of risk factors for cardiovascular disease that affects an estimated 50 million americans. the present article reviews this syndrome with respect to its def...

in nonnegative integers x, y and integers u, v ∈ {0, 1}. Note that the choice of x and y uniquely determines the choice of u and v, so we will usually refer to a solution (x, y). The Case (ra, sb) = 1 There are only a finite number of cases with N > 3 solutions to Equation (P) [23]. There are at least five infinite families of cases with N = 3 solutions to (P), as well as a number of anomalous ...

1 The Mind/Body Medical Institute, CareGroup and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, U.S.A. 2 Kliniken Essen-Mitte, Department for Internal and Integrative Medicine, 45276 Essen, Germany 3 Neuroscience Research Institute, State University of New York at Old Westbury, NY 11568, U.S.A. 4 The Carter Center Mental Health Program, At...

Address correspondence to: Ronald López-Cepero, MD, or Alberto de la Vega, MD, Department of Obstetrics and Gynecology, University of Puerto Rico School of Medicine PO BOX 365067, San Juan, PR 00936-5067. Email: ronald.lopez-cepero@ upr.edu, [email protected] Down syndrome is the most studied chromosomal abnormality, and the risk of having a child with Down syndrome increases as matern...