Background: Conduct of cardiopulmonary bypass (CPB) due to the higher volume of priming solution in comparison to the total blood volume in children requires careful consideration. Recently attention has been focused on the potential risk of hyperkalemia in these patients. Given its significant effects on cardiac rhythm, hyperkalemia is considered a medical emergency. In this cross-sectional st...

INTRODUCTION We have demonstrated that a component of post-cardiopulmonary bypass (CPB)/cardioplegic arrest (CPA) myocardial dysfunction is related to myocardial edema. Myocardial ischemia/reperfusion that occurs with CPB/CPA activates the Na(+)/H(+) exchanger to normalize intracellular pH, with intracellular Na(+) (and water) accumulation. We hypothesized that Na(+)/H(+) exchanger inhibition w...

Postoperative Atrial Fibrillation? To the Editor: The occurrence of atrial fibrillation (AF) after coronary bypass graft surgery is elevated and is the cause of perioperative complications as well as increased costs. Recently, we have demonstrated1 that the occurrence of AF is not confined to the postoperative period and that 6 months after surgery, AF is still present in 39% of the patients wh...

OBJECTIVES Hemodilution induced by cardiopulmonary bypass (CPB) often prevents open heart operations without blood transfusion because of a large CPB-priming volume. A vacuum-assisted venous drainage system appears to overcome this problem and our previous experimental study demonstrated the beneficial effect of a vacuum-assisted CPB with a pressure relief valve. In this study, we clinically ap...

Celiac plexus block (CPB) is one of the main treatment options for patients resistant to conventional antihypertensive drugs. We present a case of resistant hypertension (RHTN) that was treated with CPB using botulinum toxin. An 18-year-old male patient with RHTN, who suffered from persistent hypertension even after combination therapy and a renal denervation procedure, was referred to our pain...

We study the software performance of authenticated-encryption modes CCM, GCM, and OCB. Across a variety of platforms, we find OCB to be substantially faster than either alternative. For example, on an Intel i5 (“Clarkdale”) processor, good implementations of CCM, GCM, and OCB encrypt at around 4.2 cpb, 3.7 cpb, and 1.5 cpb, while CTR mode requires about 1.3 cpb. Still we find room for algorithm...

BACKGROUND AND PURPOSE Individualizing mean arterial blood pressure targets to a patient's cerebral blood flow autoregulatory range might prevent brain ischemia for patients undergoing cardiopulmonary bypass (CPB). This study compares the accuracy of real-time cerebral blood flow autoregulation monitoring using near-infrared spectroscopy with that of transcranial Doppler. METHODS Sixty adult ...

BACKGROUND Host defense system activation occurs with cardiopulmonary bypass (CPB) and is thought to contribute to the pathophysiological consequences of CPB. Complement inhibition effects on the post-CPB syndrome were tested with soluble complement receptor-1 (sCR1). METHODS AND RESULTS Twenty neonatal pigs (weight 1.8 to 2.8 kg) were randomized to control and sCR1-treated groups. LV pressur...

BACKGROUND AND OBJECTIVES Congenital heart diseases affect 0.8% of liveborn infants and many need neonatal surgical correction. Cardiac surgery with cardiopulmonary bypass (CPB) in this age is associated to higher risk of complications related to child's functional immaturity, lack of CPB equipment fully compatible with neonate (NN) size and technical difficulties to correct cardiac defects. Th...