original article   extended exposure to noise can cause permanent hearing damage. this study aimed to determine the incidence time of hearing loss and its effective factors in workers exposed to noise. this retrospective cohort study, was conducted on a total of 273 workers in various sectors of kerman copper by-industries co. their hearing status and the incidence of hearing loss (hearing thre...

The analysis of regression data is often improved by using a transformation of the response rather than the original response itself. However, finding a suitable transformation can be strongly affected by the influence of a few individual observations. Outliers can have an enormous impact on the fitting of statistical models and can be hard to detect due to masking and swamping. These difficult...

The determination of the software release time for a new software product is the most critical issue for designing and controlling software development processes. This paper presents an innovative technique to predict the optimal software release time using a neural network. In our approach, a three-layer perceptron neural network with multiple outputs is used, where the underlying software fau...

A new group of 4-(Imidazolylmethyl) quinoline derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para position of the C-2 phenyl ring were designed and synthesized as selective COX-2 inhibitors and in-vitro anti breast cancer agents. In-vitro COX-1 and COX-2 inhibition studies showed that all the compounds were potent and selective inhibitors of the COX-2 isozyme with IC50 value...

In this article, we propose a class of Box-Cox transformation models for recurrent event data, which includes the proportional means models as special cases. The new model offers great flexibility in formulating the effects of covariates on the mean functions of counting processes while leaving the stochastic structure completely unspecified. For the inference on the proposed models, we apply a...

To define the soil properties for a given area or country including the level of pollution, soil survey and inventory programs are essential tools. Soil data transformations enable the expression of the original data on a new scale, more suitable for data analysis. In the computer-aided interactive analysis of large data files of soil characteristics containing outliers, the diagnostic plots of...

The linear logistical isobologram is a commonly used and powerful graphical and statistical tool for analyzing the combined effects of simple chemical mixtures. In this paper a nonlinear isobologram model is proposed to analyze the joint action of chemical mixtures for quantitative dose-response relationships. This nonlinear isobologram model incorporates two additional new parameters, Ymin and...

In the use of ANOVA for hypothesis testing in animal science experiments, the assumption of homogeneity of errors often is violated because of scale effects and the nature of the measurements. We demonstrate a method for transforming data so that the assumptions of ANOVA are met (or violated to a lesser degree) and apply it in analysis of data from a physiology experiment. Our study examined wh...

Prostaglandins were discovered in human semen in 1930, but their low concentrations and instability precluded identification for nearly 30 years (for a brief historical review, see Ref. 1). Once they were identified, it was clear they arose from polyunsaturated fatty acids by a complex series of reactions involving oxygenation, cyclization, and the generation of five chiral centers from an achi...