Breast cancer is the most common neoplasm and leading cause of death in women worldwide. Although 5-fluorouracil a conventional chemotherapeutic agent for breast treatment, its use may result severe side effects. Thus, there widespread interest lowering drawbacks, without affecting therapeutic efficacy by concomitant with natural products. Herein, we aimed at evaluating whether α-mangostin, ant...

Arsenite, the trivalent form of arsenic present in the environment, is a known human carcinogen that lacked mutagenic activity in bacterial and standard mammalian cell mutation assays. We show herein that when evaluated in an assay (AL cell assay), in which both intragenic and multilocus mutations are detectable, that arsenite is in fact a strong dose-dependent mutagen and that it induces mostl...

Limes (Citrus aurantifolia Swingle) have a short postharvest life. Therefore, effective treatments increasing storage life to lengthen the time that produce remains fresh is desirable. This study evaluated effects of 1-methylcyclopropene (1-MCP), gibberellic acid (GA3), and Aloe vera on lime fruit quality. The optimum individual 50% coating, 300 mL·L−1 GA3, 750 nL·L−1 1-MCP were identified as m...

RESEARCH DESIGN AND METHODS We prospectively studied 620 participants with type 2 diabetes and HbA1c ‡58 mmol/mol (7.5%) commencing GLP-1RA therapy as part of their usual diabetes care and assessed response to therapy over 6 months. We assessed the association between baseline clinical measurements associated with b-cell failure and glycemic response (primary outcome HbA1c change 0–6 months) wi...