The contribution of this paper is to propose and justify two general rules that can help to argue the costeffectiveness of use of the formal modelling language Coloured Petri Nets (CPN): (1) Construction of CPN models should be explicitly based on high-quality documentation that software developers already produce; (2) Use of CPN models should be explicitly seen as prototyping. Rule (1) enables...

■■ Cost-Effectiveness of Pazopanib Versus Sunitinib for Renal Cancer in the United States We write to comment on a recently published study by Delea et al. in the January 2015 issue of JMCP that evaluated the costeffectiveness (CE) of sunitinib (SU) versus pazopanib (PAZ) as first-line treatment for metastatic renal cell carcinoma (mRCC) from a U.S. third-party payer perspective. This analysis ...

ABSTRACT Managed care organizations and pharmacy benefit managers often use tiered formularies to contain drug costs. Cost is one factor used to decide tier placement. Drug prices alone may not reflect the true cost of using particular drugs within a class. A decision-analytic model of the serotonin reuptake inhibitor (SRI) class of antidepressants was reviewed. SRIs include selective serotonin...

This article presents analysis and synthesis of findings concerning the problem of costeffective placement of best management practices (BMPs) emerging from NIFA CEAP and the USDA NRCS jointly-funded competitive grant projects, and future research needs. The synthesis focuses on two fundamental aspects of the cost-effectiveness problem: (1) how to assess the locationand farmer-specific costs of...

There is a growing interest in customer-owned generation with a particular interest in photovoltaic (PV) systems. This has resulted in a growing number of analytical studies aimed at determining their value. Two difficulties that these studies have encountered are how to select the proper evaluation perspective and which benefits and costs to include in the analysis. This paper presents a frame...

This paper presents an evaluation of battery requirements for hybrid and electric city buses. Technical specifications of recently developed lithium based batteries and vehicle simulation results are used as basis for the evaluation. The battery requirements are evaluated in terms of power and energy capacity, calendar and cycle life as well as costs. Conventional diesel, parallel and series hy...

The choice of model design for decision analytic models in cost-effectiveness analysis has been the subject of discussion. The current work addresses this issue by noting that, when time is to be explicitly modelled, we need to represent phenomena occurring in continuous time. Multistate models evaluated in continuous time might be used but closed form solutions of expected time in each state m...

INTRODUCTION Multidrug-resistant (MDR) Gram-negative healthcare-associated infections are prevalent in Singaporean hospitals. An accurate assessment of the socioeconomic impact of these infections is necessary in order to facilitate appropriate resource allocation, and to judge the costeffectiveness of targeted interventions. MATERIALS AND METHODS A retrospective cohort study involving inpati...

Background: In the last decade, a number of new treatment modalities have been developed for patients with small cell lung cancer (SCLC). The clinical effects are encouraging, but little is known about the costs and cost-effectiveness of new drugs. Methods: A Markov chain model has been developed to project patient outcomes and costs for patients with advanced SCLC. All patients in the control ...

We greatly appreciate the comments of Dr. Rutte et al. regarding our recent study on the effectiveness of sexual counseling models in health care [1]. We agree with them that to find a more cost-effective alternative for standard models, such as Permission, Limited Information, Specific Suggestions, and Intensive Therapy (PLISSIT), we should perform a costeffectiveness study. We will need furth...