Abstract Corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus of hypothalamus are canonical controllers endocrine response to stress. Here we propose a new role for these cells as gate state transitions that allow organism engage stress-related behaviors. Specifically, review evidence indicating activation at critical times allows organisms move is permissive motor actio...

Hypertension in the elderly is a common problem that often found. Many factors affect hypertension elderly, so it necessary to empower them elderly. The purpose of this empowerment control blood pressure through progressive muscle relaxation (PMR) techniques. method used counselling and exercise demonstration, which consists 3 main activities: screening, PMR technique training, activity evaluat...

Urocortin 1 (UCN1) is a corticotropin-releasing factor (CRF)-like peptide whose role in stress is not well characterized. To study the physiological role of UCN1 in the response of the hypothalamic-pituitary-adrenal (HPA) axis to stress, we generated UCN1-knockout (KO) mice and examined their adaptation to repeated restraint and to cold environment. Wild-type (WT) and UCN1-KO animals were restr...

ACTH-releasing potency of a purified hypothalamic CRF of pig origin was examined by use of the intrapituitary microinjection method. A good log doseresponse relationship was obtained in the dosage range from 12.5 to 50 ng injected per one anterior pituitary lobe. Two dose factorial analysis showed that the difference in response between purified CRF and median eminence extract of the rat at cor...

Vasopressin (AVP), produced in parvocellular neurons of the hypothalamic paraventricular nucleus, regulates, together with CRH, pituitary ACTH secretion. The pituitary actions of AVP are mediated through the G protein receptor V(1b) (V(1b)|R). In man, hyperactivity of the hypothalamic-pituitary-adrenal axis has been associated with depression and other stress-related conditions. There are also ...

Corticotropin-releasing hormone (CRH), a 41 amino acid polypeptide, is expressed in many regions of central nervous system and peripheral tissues and mediates many physiological functions. Abnormal production of CRH is involved in some pathological processes. Among various endogenous factors that modulate CRH production, steroid hormones control CRH production by regulating its gene transcripti...