introduction atherosclerosis is a disease which begins during childhood. oxidation of lipoproteins is an important factor implicated in atherosclerosis. vitamin c decreases blood serum lipids and may inhibit atherosclerosis. this study was designed to observe the effect of ascorbic acid on blood serum lipids in male rabbits fed high-cholesterol diet. methods twenty white male rabbits were weigh...

Traditional risk factors are poor screening tests for coronary heart disease, whereas clinical arterial disease represents its strongest predictor. This raises the question whether subclinical arterial disease may also predict coronary disease. Using published data of prospective studies of subclinical arterial disease, we calculated the incidence of coronary event associated with the absence o...

Prolonged testing of marine fish oil (FO) as a dietary supplement is necessary because of widespread claims that it is antiatherogenic The basis for such claims is inadequate because atherogenesis is chronic and may not respond to short-term changes induced by dietary treatments. A proven (vervet) model of atherosclerosis promoted by an atherogenic diet (AD) was used to test dietary supplementa...

Atherosclerosis is mediated by local and systematic inflammation. The multiligand receptor for advanced glycation end products (RAGE) has been studied in animals and humans and is an important mediator of inflammation and atherosclerosis. This review focuses on S100/calgranulin proteins (S100A8, S100A9, and S100A12) and their receptor RAGE in mediating vascular inflammation. Mice lack the gene ...

Prolonged testing of marine fish oil (FO) as a dietary supplement is necessary because of widespread claims that it is antiatherogenic. The basis for such claims is inadequate because atherogenesis is chronic and may not respond to short-term changes induced by dietary treatments. A proven (vervet) model of atherosclerosis promoted by an atherogenic diet (AD) was used to test dietary supplement...

BACKGROUND Ischemic heart disease (IHD) following atherosclerosis is a giant killer and the incidence of atherosclerosis in coronary arteries is rapidly increasing among Indians. The study was formulated to assess the histomorphological atherosclerotic changes in aorta and coronary arteries at autopsy by applying the modified American Heart Association classification of atherosclerosis based on...

OBJECTIVES Highlighted the spectrum of coronary atherosclerosis in asymptomatic population by Computed Tomography Angiography (CTA) and developed a surrogation of expensive CTA to early detect coronary atherosclerosis. METHODS Three hundred and seven self-referred urban Han Chinese asymptomatic individuals underwent coronary CTA were consecutively enrolled. Total plaque score (TPS), Segment s...

Background: Coronary artery bypass grafting (CABG) continues to be the best standard in management of severe coronary disease (CAD), providing good symptom and life extension. Although CABG was first performed by reversed saphenous veins (SVGs), surgeons have increasingly adopted arterial conduits because their longer-term patency resistance atherosclerosis. CABG's efficacy may potentially affe...

Many clinical studies support the opinion that carotid intima-media thickness (IMT) assessed by B-mode ultrasound in extracranial carotid arteries, either in a single segment (common carotid) or in multiple segments (aggregate of measures in common carotids, bifurcations, and internal carotids), is a valuable mirror of coronary risk status and a worthwhile predictor of subsequent coronary heart...