PURPOSE The precise molecular mechanisms culminating in coronary artery disease (CAD) are not well understood, despite a wealth of knowledge on predisposing risk factors and pathomechanisms. CAD and myocardial infarction (MI) are complex genetic diseases; neither the environment alone, nor a single gene, cause disease, rather, a mix of environmental and genetic factors lead to atherosclerosis o...

Background & Aims: Significant left main coronary artery disease (LMCAD) is found in 3 to 6 percent of all patients who undergo coronary arteriography. LMCAD usually requires an emergent surgery that has a higher rate of mortality and complications. The risk factors of left main involvement in previous studies are controversial. The aim of this study was to determine the traditional risk factor...

background: it is hypothesized that the impacts of life events accumulate and can trigger and promote atherosclerosis in susceptible individuals. in the current study, the correlation of total life stressors during 1 year was investigated relative to coronary artery disease (cad). methods: the study population consisted of 148 males and 152 females aged 35–76 years. the subjects were classified...

OBJECTIVE To investigate the role of Brachial ankle Pulse Wave Relocity (baPWV) and cfPWV on the risk of Coronary artery disease and the interaction between baPWV and risk factors of Coronary artery disease (CAD). METHODS A case-control study was conducted at Department of Emergency, SunYat-Sen memorial Hospital, China. We collected 332 cases with coronary artery disease and 328 subjects with...

BACKGROUND It is unclear whether coronary artery stenosis affects the secretion of N-terminal pro-brain natriuretic peptide (NT-proBNP) and brain natriuretic peptide (BNP) from the heart independent of ventricular dysfunction. Therefore, this study evaluated the relationship between BNP and NT-proBNP secretion, plasma levels and the severity of coronary artery stenosis in patients with stable c...

OBJECTIVE Increased carotid artery intima-media thickness (IMT) and increased coronary artery calcium (CAC) are noninvasive surrogate indices of prevalent coronary artery disease (CAD). We compared CAC to IMT for noninvasive detection of prevalent CAD in participants whose coronary status was identified by coronary angiography. METHODS AND RESULTS Male and female CAD patients (> or =50% steno...

OBJECTIVES The purpose of this study was to determine the relationship among coronary atherosclerosis and functional, morphologic, and mechanical parameters assessed noninvasively within the brachial artery (BA). BACKGROUND Flow-mediated vasodilation (FMD) of the BA, intima-media thickness (IMT) of the carotid artery, and distensibility of the aorta have been correlated with the presence of c...

INTRODUCTION EAT is an independent factor in coronary artery disease (CAD). The objective of the current study was to define an echocardiographic cut-off point for EAT and to determine its diagnostic value in predicting the increase in CAD risk. METHODS Two hundred patients underwent coronary artery angiography for diagnosis of CAD and transthoracic echocardiography for measurement of EAT on ...

CME 2004 Introduction In diabetes mellitus, morbidity and mortality secondary to cardiovascular diseases has increased these days since the morbidity and mortality related to infections and ketosis has decreased. Diabetics mellitus (DM) has a greater prevalence of coronary artery disease (CAD), cardiomyopathy and congestive cardiac failure.1 Metabolic abnormalities and dyslipidemias associated ...