A human corneal epithelial cell line, 10.014 pRSV-T (HCR-T cells), has been used to develop a three-dimensional in vitro model of the human corneal epithelium (HCE-T model). HCE-T cells form a stratified culture when grown at the air-liquid interface on a collagen membrane in serum-free medium. This model served as the basis for assays which supported the ocular irritancy assessment of water-so...

Dry eye syndrome (DES) is one of the most common types of ocular diseases. There is a major need to treat DES in a simple yet efficient way. Artificial tears (AT) are the most commonly used agents for treating DES, but are not very effective. Herbal extractions of ferulic acid (FA), an anti-oxidant agent, and kaempferol (KM), an anti-inflammatory reagent, were added to buffer solution (BS) to r...

in the present study, the effects of the acute and chronic oral administrations (po) of curcumin in the absence and presence of morphine and naloxone was investigated on the sensation of acute corneal pain in rats. acute corneal pain was induced by the local application of hypertonic saline (5 m nacl) on the corneal surface, and the number of eye wipes was then counted for 30 s. subcutaneous (s...

purpose: to determine the indications for and surgical techniques of corneal transplantation at labbafinejad medical center (lmc) from 2004 to 2007. methods: in this descriptive study, records of 756 patients who had undergone corneal transplantation from october 2004 to october 2007 were reviewed. results: overall, 504 male (64.9%) and 272 female (35.1%) subjects with mean age of 41.29±21.25 (...

purpose: to evaluate corneal thickness changes after soft contact lens (scl) removal in lasik candidates. methods: fifty lasik candidates (100 eyes) with history of daily wear scl for at least 6 months were enrolled in this descriptive study. central corneal thickness was measured by ultrasonic pachymetry immediately after lens removal and then repeated daily at the same time, until the thickne...

purpose: to specify histopathologic features of corneal involvement in a case with xeroderma pigmentosum (xp). case report: a 19-year-old man with a clinical diagnosis of xp presented with bilateral corneal leukoma and decreased visual acuity predominatly in his right eye. penetrating keratoplasty was performed in the right eye due to severe corneal opacity, vascularization and lipid deposition...

310 There are few reports of spontaneous ocular changes in laboratory rabbits (1), which when detected may complicate interpretation of ocular results in toxicity testing. The corneal changes that have been described in this species include anterior corneal dystrophy in American Dutch belted rabbits (2) and corneal epithelial dystrophy in New Zealand White (NZW) rabbits (3, 4). In addition, die...

The present study investigated the effects of microinjections of acetylcholine (a cholinergic agonist), physostigmine (a cholinesterase inhibitor), atropine (an antagonist of muscarinic cholinergic receptors) and hexamethonium (an antagonist of nicotinic cholinergic receptors) into the parafascicular nucleus of thalamus on the acute corneal nociception in rats. Acute corneal nociception was ind...

purpose: to evaluate the effect of topical phenytoin 1 % on corneal epithelial defects healing in a rabbit model. methods: one eye of 20 albino rabbits in the animal house of al-zahra ophthalmology hospital was studied. a single corneal epithelial defect was created. the rabbits were randomly assigned into two groups (ten animals in each group). after creating a chemical burn in rabbits, one gr...