AIMS The tonographic effect is a phenomenon of intraocular pressure (IOP) reduction following repeated tonometry. This study examines whether the tonographic effect occurs following IOP measurement performed with Ocular Response Analyzer (ORA). METHODS Both eyes of 31 glaucoma patients and 35 healthy controls underwent nine IOP-measurements performed with GAT and ORA. The number of GAT and OR...

AIMS To determine the influence of prostaglandin analogues (PGAs) on corneal biomechanical properties in patients undergoing chronic treatment for primary open-angle glaucoma (POAG). METHODS Prospective, interventional case-control study. 70 eyes from 35 patients with POAG on chronic PGA therapy were recruited. One eye per patient underwent PGA cessation for 6 weeks while the contralateral ey...

BACKGROUND Corneal perforation is an uncommon complication associated with keratoconus. The first cases of infectious keratitis and corneal perforation associated with corneal hydrops and contact lens wear are reported in two keratoconus patients. METHODS A retrospective chart review and histopathological examination were carried out. RESULTS Both patients progressed to corneal perforation ...

PURPOSE The aim of this study was to evaluate the accuracy of intraocular pressure (IOP) values from the new non-contact tonometer (NCT) Reichert R7 by comparing results with those from Goldmann applanation tonometry (GAT) and the Reichert Ocular Response Analyzer (ORA). Other ocular dimensions were assessed to evaluate their potential influence on the IOP values obtained. METHODS Ninety two ...

eight genotypes of spring safflower (carthamus tinctorius l.) were evaluated for several physiological traits under stress and non-stress water regimes. data were analyzed using principal factor analysis. the factor analysis technique extracted six factors under non-stress conditions. six factors explained about 80% of the total variation, and only 40% of the variance was accounted for by the f...

Corneal neovascularization (NV) not only reduces visual acuity, but it also causes loss of the cornea's immune privilege, strongly contributing to a worse prognosis in penetrating keratoplasty. Several mediators participate in corneal angiogenesis, and the role of vascular endothelial growth factor (VEGF) has been extensively proven. Anti-VEGF agents have been shown to be effective in slowing t...

The corneal epithelium plays important roles in the maintenance of corneal transparency for good vision, and acts as a protective barrier against foreign insults. Structural and functional changes with aging in the corneal epithelium have been documented. Here we found that transforming growth factor-β (TGF-β) is highly expressed in the elderly donor corneal epithelium, as are senescence-associ...

PURPOSE. Previous studies have suggested no role for tumor necrosis factor (TNF)-a in the modulation of apoptosis in corneal fibroblasts. However, recent investigations have demonstrated that nuclear factor (NF)-kB activation by TNF-a mediates negative apoptotic effects that must be blocked to unmask the apoptotic effects of TNF-a in vitro. The purpose of this study was to investigate the role ...

Inflammation and angiogenesis are integral parts of wound healing. However, excessive and persistent wound-induced inflammation and angiogenesis in an avascular tissue such as the cornea may be associated with scarring and visual impairment. Junctional adhesion molecule A (Jam-A) is a tight junction protein that regulates leukocyte transmigration as well as fibroblast growth factor-2 (FGF-2)-in...

The barrier function of the corneal epithelium maintains corneal homeostasis and is mediated by tight junctions (TJs) and adherens junctions (AJs). It is also susceptible to disruption by hypoxia. We have now examined the effects of hypoxia on TJs and AJs as well as on barrier function in human corneal epithelial (HCE) cells. Moreover, we investigated whether such effects of hypoxia might be mo...