purpose: to evaluate corneal thickness changes after soft contact lens (scl) removal in lasik candidates. methods: fifty lasik candidates (100 eyes) with history of daily wear scl for at least 6 months were enrolled in this descriptive study. central corneal thickness was measured by ultrasonic pachymetry immediately after lens removal and then repeated daily at the same time, until the thickne...

purpose: to specify histopathologic features of corneal involvement in a case with xeroderma pigmentosum (xp). case report: a 19-year-old man with a clinical diagnosis of xp presented with bilateral corneal leukoma and decreased visual acuity predominatly in his right eye. penetrating keratoplasty was performed in the right eye due to severe corneal opacity, vascularization and lipid deposition...

Diosgenin is a natural steroid sourced from plants and exhibits good analgesic anti-inflammatory activity. However, mechanism of action associated with the activity diosgenin not yet delineated. Hence, in present study, we explored on nitric oxide/cyclic guanosine monophosphate/adenosine monophosphate sensitive potassium channels (NO/cGMP/kATP). The role (NO/cGMP/kATP) Wistar rat was studied us...

In this study, 12 new 3-methyl-6-(2-substituted aminopropanoyl)-2-benzoxazolinone and 3-methyl-6-(1-hydroxy-2-substituted aminopropyl)-2-benzoxazolinone derivatives have been prepared. Their structures have been elucidated by IR, 1H NMR spectra and by elementary analysis. The anti-nociceptive activity of these compounds has been investigated by using a modified Koster test. It was found that mo...

purpose: to evaluate the effect of topical phenytoin 1 % on corneal epithelial defects healing in a rabbit model. methods: one eye of 20 albino rabbits in the animal house of al-zahra ophthalmology hospital was studied. a single corneal epithelial defect was created. the rabbits were randomly assigned into two groups (ten animals in each group). after creating a chemical burn in rabbits, one gr...

(R)-(+)-Pulegone is a monoterpene found in essential oils from plants of the Labiatae family. This compound is a major constituent of Agastache formosanum oil. In this study, the effect of (R)-(+)-pulegone on the central nervous system was evaluated. (R)-(+)-Pulegone caused a significant decrease in ambulation and an increase in pentobarbital-induced sleeping time in mice, indicating a central ...

Evidence suggests that the arterial baroreceptors modulate pain. To examine whether cortical processing of nociception is modulated by natural variations in arterial baroreceptor stimulation during the cardiac cycle, peak-to-peak amplitudes of the N2-P2 pain-related potential and pain ratings were recorded in response to noxious laser stimulation at different times during the cardiac cycle in 1...

The neuropeptide galanin is widely expressed in the nervous system and has an important role in nociception. It has been shown that galanin can facilitate and inhibit nociception in a dose-dependent manner, principally through the central nervous system, with enhanced antinociceptive actions after nerve injury. However, following nerve injury, expression of galanin within the peripheral nervous...

The current knowledge about heat nociception is mainly confined to the thermosensors, including the transient receptor potential cation channel V1 expressed in the nociceptive neurons of dorsal root ganglion (DRG). However, the loss of thermosensors only partially impairs heat nociception, suggesting the existence of undiscovered mechanisms. We found that the loss of an intracellular fibroblast...