Background: To evaluate the agreement in intraocular pressure (IOP) measurements by Ocular Response Analyzer (ORA) and Tono-Pen XL (TXL) with the Goldmann Applanation Tonometer (GAT) and to examine corneal biomechanical properties in aphakic glaucoma patients with a central corneal thickness (CCT) >600 µ. Methods: Thirty-six eyes of aphakic glaucoma patients (group 1) and 40 eyes of normal chil...

Physiological studies have demonstrated that ions, as well as large molecules such as hemoglobin or fluorescein, can diffuse across and within the cornea. Most of the substrates for corneal metabolism are obtained from aqueous humor filling the anterior chamber. In order to receive its nutrients and in order to maintain its normal conditions of hydration, the avascular cornea must transport rel...

occur postoperatively) have recently been implicated as possible markers of corneal endothelial cell damage. We have examined this phenomenon in vivo with the slit-lamp and specular microscope. We recognised three types of linear form and, in contradiction of other observers, found that each was always coincident with a wrinkle in Descemet's membrane. Moreover, we were able to demonstrate only ...

Program Number: 1300 Presentation Time: 8:30 AM–8:45 AM Retinoic Acid Improves Keratocyte Phenotype in a 3D Model of the Corneal Stroma Ricardo M. Gouveia, Fadhilah Z. Abidin, Che J. Connon. Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom. Purpose: Retinoic Acid (RA) is a metabolite of vitamin A fundamental for the correct function and development of the...

Lymphangiogenesis is associated with pathological processes such as the metastatic spread of carcinoma cells and organization of immunologically active lymphocytic infiltrates following organ transplantation. It has not yet been established whether expansion of the lymphatic vascular meshwork is driven by incorporation of progenitor cells or by local endothelial cell division. In this issue of ...

The cornea is the transparent outermost surface of the eye, consisting of a stratified epithelium, a collagenous stroma and an innermost single-cell layered endothelium and providing 2/3 of the refractive power of the eye. Multiple diseases of the cornea arise from genetic defects where the ultimate phenotype can be influenced by cross talk between the cell types and the extracellular matrix. C...

BACKGROUND Congenital hereditary endothelial dystrophy (CHED) is a corneal dystrophy characterised by diffuse bilateral corneal clouding resulting in impaired vision. It is inherited in either an autosomal dominant (AD) or autosomal recessive (AR) manner. The AD form of CHED has been mapped to the pericentromeric region of chromosome 20. Another endothelial dystrophy, posterior polymorphous dys...

PURPOSE To describe the clinical, ocular, and genetic findings in multiple members of a family with early-onset and bilateral lens dislocation, clinical corneal guttae, and glaucoma. METHODS All family members underwent complete physical and ophthalmic examinations. After informed consent was given, DNA was obtained from eleven family members, eight of whom were affected. Three polymorphic ma...