PURPOSE To determine intraoperative changes in corneal thickness and outcomes of corneal collagen crosslinking (CXL) using 2 intraoperative regimens: riboflavin-dextran or hypotonic riboflavin. SETTING Cornea and refractive surgery practice, Teaneck, New Jersey, USA. DESIGN Prospective randomized case series. METHODS Eyes with keratoconus or corneal ectasia were treated. All eyes received...

BACKGROUND In this study, we used a Pentacam® device to evaluate the corneal changes that occur after laser-assisted in situ keratomileusis (LASIK). METHODS Our study included 60 eyes of 32 patients. All patients were treated for myopia and myopic astigmatism using LASIK. The eyes were examined preoperatively and 3 months postoperatively using a Pentacam to assess corneal changes with regard ...

The management of high postoperative astigmatism remains a major challenge for corneal refractive surgeons and various techniques have been evaluated.1 The recent introduction and development of femtosecond laser-assisted keratotomy could potentially combine a wide range of corrections with the accuracy and safety of laser treatment.2,3 Assessing the long-term visual and keratometric outcomes o...

Collagen crosslinking is a relatively new treatment for structural disorders of corneal ectasia, such as keratoconus. However, there is a lack of animal models of keratoconus, which has been an obstacle for carefully analyzing the mechanisms of crosslinking and evaluating new therapies. In this study, we treated rabbit eyes with collagenase and chondroitinase enzymes to generate ex vivo corneal...

BACKGROUND To evaluate the 5-year results of Refractive Lenticule Extraction (ReLEx) as Small Incision Lenticule Extraction (SMILE) technique for treatment of myopia and myopic astigmatism. METHODS In 2008/2009, the worldwide first 91 eyes were treated using a novel surgical technique (SMILE), where a refractive lenticule of intrastromal corneal tissue is removed though a small incision compl...

We were very interested to read of a second mutation in the seed region of miR-184 resulting in EDICT syndrome. We were unsure after reading the paper, however, of how the corneal findings should be classified and of the statement that the family “does not demonstrate a keratoconus phenotype.” Keratoconus, the commonest disorder of corneal thinning and steepening, has been linked with VSX1 and ...

PURPOSE Corneal collagen crosslinking (CXL) is designed to halt the progression of keratoconus and corneal ectasia by inducing corneal stiffening. However, it currently is difficult to monitor and evaluate CXL outcome objectively due to the lack of suitable methods to characterize corneal mechanical properties. We validated noncontact Brillouin microscopy to quantify corneal mechanical properti...

PURPOSE To evaluate the long-term outcomes of two-step versus single application of mitomycin-C (MMC) during photorefractive keratectomy (PRK) for high myopia. METHODS This randomized clinical trial included consecutive patients with high myopia (exceeding 7 D). Patients underwent PRK and were randomized to two methods of MMC 0.02% application as follows: in the single application group, MMC ...

To compare the efficacy of epithelium-off corneal collagen crosslinking (CXL) with transepithelial CXL in patients progressive keratoconus a follow-up 3 years, taking into account patients’ age and location ectasia. In this prospective study participated 64 eyes were included long-term study, which 31 treated by 33 CXL. All 36 months evaluated for visual variables (corrected distance acuity (CD...