The t(8;21) translocation between two genes known as AML1 and ETO is seen in approximately 12-15% of all acute myeloid leukemia (AML) and is the second-most-frequently observed nonrandom genetic alteration associated with AML. AML1 up-regulates a number of target genes critical to normal hematopoiesis, whereas the AML1/ETO fusion interferes with this trans-activation. We discovered that the fus...

COPD is a major cause of chronic morbidity and mortality throughout the world. Cor pulmonale is a strong predictor of death in COPD. Early diagnosis of cor pulmonale in COPD plays a vital role. The present study was undertaken to make an early diagnosis of cor pulmonale in COPD and to correlate clinically the findings of echocardiography in presence or absence of pulmonary hypertension. One hun...

Coronamic acid (CMA; 2-ethyl-1-aminocyclopropane 1-carboxylic acid) is an intermediate in the biosynthesis of coronatine (COR), a chlorosis-inducing phytotoxin produced by Pseudomonas syringae pv. glycinea PG4180. Tn5 mutagenesis and substrate feeding studies were previously used to characterize regions of the COR biosynthetic gene cluster required for synthesis of coronafacic acid and CMA, whi...

Endothelium-derived relaxing factors may differentially modulate vascular tone and relaxation in arteries from specific vascular beds. We evaluated the role of nitric oxide (NO), prostacyclin (PGI2) and endothelium-derived hyperpolarizing factor in determining basal tone and acetylcholine (ACh)-induced relaxation of coronary (Cor), skeletal muscle (Ske) and mesenteric (Mes) small arteries (150-...

Mauricio Alvarez, Arnaldo Azevedo, Cor Meenderinck, Ben Juurlink, Andrei Terechko, Jan Hoogerbrugge, Alex Ramirez Technical University of Catalonia (UPC), Barcelona, Spain Delft University of Technology, Delft, The Netherlands NXP, Eindhoven, The Netherlands Barcelona Supercomputing Center (BSC), Barcelona, Spain Email: [email protected], {azevedo, cor, benj}@ce.et.tudelft.nl, {andrei.terechko...

Curved corannulene (Cor) can produce reactive oxygen species (ROS) in a controlled manner due to the large dipole moment. However, the poor aqueous solubility of Cor necessitates the employment of solubilization vehicles. This work revealed that PEGylation was less efficient than the cyclodextrin complexation regarding ROS production.

Esse ensaio teórico buscou refletir sobre o neoliberalismo contemporâneo. A partir da história do Brasil, intersecionada por opressões, as quais foram, sistematicamente, engendradas e convergiram em estruturas racistas, capitalistas heterocispatriarcais. Iniciamos com a reflexão de que, mesmo capitalismo, seguindo uma lógica, é diferenciado pelo processo histórico nos modos produção na acumulaç...

The corepressors N-CoR (nuclear receptor corepressor) and SMRT (silencing mediator for retinoid and thyroid hormone receptors) interact with unliganded nuclear hormone receptors, including thyroid hormone (T(3)) receptor (TR). Several N-CoR/SMRT complexes containing histone deacetylases have been purified. The best studied among them are N-CoR/SMRT complexes containing TBL1 (transducin beta-lik...