The marine biotoxin domoic acid (DA) is an analog of the neurotransmitter glutamate that exerts potent excitatory activity in brain, heart, and other tissues. Produced by diatom Pseudo-nitzschia spp., DA accumulates invertebrates, fish, sediment. Southern sea otters ( Enhydra lutris nereis ) feed primarily on including crabs bivalves, concentrate slowly depurate DA. Due to their high prey consu...