Seven lesions are presented in which short TR/short TE images obtained immediately after IV administration of gadopentetate dimeglumine demonstrated an apparent decrease in signal intensity compared with precontrast short TR/short TE images. All seven lesions were hyperintense on precontrast short TR/short TE images. In four cases in which long TR/long TE scans were also obtained, the lesions w...

We report a methodology which enables the preparation of dendrimeric contrast agents sensitive to Ca(2+) when starting from the monomeric analogue. The Ca-triggered longitudinal relaxivity response of these agents is not compromised by undertaking synthetic transformations, despite structural changes. The in vivo MRI studies in the rat cerebral cortex indicate that diffusion properties of dendr...

This theme issue provides a timely overview on the current status of stem cell tracking with the nanoparticle-based contrast agents.

The synthetic protocol for preparation of 1-(13)C-phosphoenolpyruvate-d2, precursor for parahydrogen-induced polarization (PHIP) of 1-(13)C-phospholactate-d2, is reported. (13)C nuclear spin polarization of 1-(13)C-phospholactate-d2 was increased by >30,000,000-fold (5.75 mT) in water. The reported (13)C polarization level approaching unity (>15.6%), long lifetime of (13)C hyperpolarized 1-(13)...

Several pulse sequences have been used to detect paramagnetic chemical exchange saturation transfer (PARACEST) contrast agents in animals to quantify the uptake over time following a bolus injection. The observed signal change is a combination of relaxation effects and PARACEST contrast. The purpose of the current study was to isolate the PARACEST effect from the changes in bulk water relaxatio...

The importance of ultrasound examination in the diagnosis of breast cancer has been widely demonstrated. During the last few years, the introduction of ultrasound contrast media has been considered a promising tool for studying the vascular pattern of focal lesions within the breast. Our purpose was to assess whether contrast-enhanced (CE) ultrasound examination, performed using specific contra...

Previous research has shown age-related differences in discriminating motion at different levels of contrast (Betts et al., 2005, 2009, 2012). A surprising result of this research is that older as compared to younger observers showed improved performance in detecting motion of large high-contrast stimuli suggesting age-related differences in center-surround antagonism. In the present study we e...

M. V. Terekhov, V. Sen', V. Golubev, S. Weber, A. W. Scholz, T. Muenzel, A. L. Kleschyov, and L. M. Schreiber Department of Radiology, Section of Medical Physics, Johannes Gutenberg University Medical Center Mainz, Mainz, Germany, Institute of Problems of Chemical Physics, Russian Academy of Sciences, Russian Federation, Department of Anesthesiology, Johannes Gutenberg University Medical Center...