Ventricular geometry and fiber orientation may undergo global or local remodeling in cardiac disease. However, there are as yet no mathematical and computational methods for quantifying variation of geometry and fiber orientation or the nature of their remodeling in disease. Toward this goal, a landmark and image intensity-based large deformation diffeomorphic metric mapping (LDDMM) method to t...

Research of the human brain connectome requires multiscale approaches derived from independent imaging methods ideally applied to the same object. Hence, comprehensible strategies for data integration across modalities and across scales are essential. We have successfully established a concept to bridge the spatial scales from microscopic fiber orientation measurements based on 3D-Polarized Lig...

Heterogeneity in cardiac tissue microstructure is a potential mechanism for the generation and maintenance of arrhythmias. Abnormal changes in fiber orientation increase the likelihood of arrhythmia. We present optical coherence tomography (OCT) as a method to image myofibers in excised intact heart preparations. Three-dimensional (3-D) image sets were gathered from the rabbit right ventricular...

BACKGROUND Accurate interpretations of cardiac functions require precise structural models of the myocardium, but the latter is not available always and for all species. Although scaling or substitution of myocardial fiber information from alternate species has been used in cardiac functional modeling, the validity of such practice has not been tested. METHODS Fixed mouse (n = 10), rabbit (n ...

1 Abstract Bio-based materials offer interesting solutions to sustainable and eco-friendly industrial applications in the future. In this study micromechanical modeling and Mori-Tanaka mean field homogenization technique is used for stiffness prediction in short flax fiber reinforced PLA biopolymer. The fiber geometry distribution is considered in the homogenization along with the orientation d...

Abstract Adding steel fibers to concrete improves the post-cracking tensile strength of composite material due bridging cracks. The residual performance is influenced by fiber type, content and orientation with respect crack plane. latter a main issue in fiber-reinforced elements, since it significantly influences structural behavior. aim this research develop tailor-made casting method orient ...

Diffusion-weighted MRI has enabled the imaging of white matter architecture in vivo. Fiber orientations have classically been assumed to lie along the major eigenvector of the diffusion tensor, but this approach has well-characterized shortcomings in voxels containing multiple fiber populations. Recently proposed methods for recovery of fiber orientation via spherical deconvolution utilize a sp...