BACKGROUND This position paper presents some of the challenges experienced in relation to an outsourced usability evaluation of commercial collaboration product, which we would like to raise in the Improving the Interplay between Usability Evaluation and User Interface Design workshop. The paper describes the context of the outsourced evaluation, three challenges of location, how the evaluation...

While sympathetic stimulation of the heart produces chronotropic, inotropic, and lusitropic effects, increased frequency alone causes a positive forcefrequency relationship (FFR) and frequency-dependent acceleration of relaxation (FDAR).1 That is, contraction amplitude and relaxation rate are increased with increasing frequency in most species (including humans). The key mechanism involved in t...

People tend to overestimate the emotional consequences of future life events, exhibiting an impact bias. The authors replicated the impact bias in a real-life context in which undergraduates were randomly assigned to dormitories (or "houses"). Participants appeared to focus on the wrong factors when imagining their future happiness in the houses. They placed far greater weight on highly variabl...

We investigated infants' sensitivity to spatiotemporal structure. In Experiment 1, circles appeared in a statistically defined spatial pattern. At test 11-month-olds, but not 8-month-olds, looked longer at a novel spatial sequence. Experiment 2 presented different color/shape stimuli, but only the location sequence was violated during test; 8-month-olds preferred the novel spatial structure, bu...

Increased deployment of intermittent renewable energy resources — wind energy in particular — has the potential to deliver cost e¤ective GHG emissions in the near term. Accurate quanti…cation of the environmental bene…ts from these resources has an important role to play in policy design, implementation, and evaluation. This paper develops an empirical approach to estimating marginal operating ...

From the Division of General and Community Pediatrics (Drs Real, Beck, and Klein), Division of Hospital Medicine (Drs Beck and Klein), Cincinnati Children’s Hospital Medical Center, Ohio; and Division of General Pediatrics, Boston Medical Center (Dr Michelson), Mass The authors have no conflicts of interest to disclose. Address correspondence to Francis J. Real, MD, 3333 Burnet Ave, MLC 2011, C...

The metastasis suppressor, BRMS1, has been demonstrated to cause dramatic regression of metastatic lesions without blocking orthotopic tumor growth. The role of BRMS1 is well-documented for several non-melanoma malignancies, such as breast cancer, ovarian cancer and non-small-cell lung cancer. However, its role in melanoma is just beginning to be understood, with a recent article by Slipicevic ...

The past decade has witnessed the evolution of a new paradigm in thinking about the intimate interrelationship between cellular structure and physiological function in biological processes. It is not surprising that this evolution has, perhaps, its clearest history in the field of excitation-contraction (E-C) coupling, which has had to wrestle with the long-standing paradox of how the release o...

Neurons may be particularly sensitive to disruptions in transcription factor trafficking. Survival and injury signals must traverse dendrites or axons, in addition to soma, to affect nuclear transcriptional responses. Transcription factors exhibit continued nucleocytoplasmic shuttling; the predominant localization is regulated by binding to anchoring proteins that mask nuclear localization/expo...