The role of gamma-aminobutyric acid B (GABA(B)) receptors in the generation and maintenance of bicuculline-induced epileptiform activity in rat neocortical slices was studied using electrophysiological methods. A block of GABA(B) receptors in the presence of functional GABA(A) receptor-mediated inhibition was not sufficient to induce epileptiform activity. In the presence of the GABA(A) recepto...

Abstract Disturbances of GABAergic inhibition are a major cause of epileptic seizures. GABA exerts its actions via ionotropic GABAA receptors and metabotropic G protein-coupled GABAB receptors. Malfunction of GABAA inhibition has long been recognized in seizure genesis but the role of GABAB receptors in controlling seizure activity is still not well understood. Here, we examined the anticonvuls...

Background: Deficits in upper body movement have received little attention during gait in cerebral palsy (CP) children with crouch gait pattern (CGP).Objective: Purpose of this research is to describe the correlation of trunk movement with the excessive knee flexion and ankle kinematic in CP children with CGP.Methods: Gait analysis data from 57 limbs of diplegic CP children with CGP and 26 limb...

Boolean functions represent an important primitive when constructing many stream ciphers. Since they are often the only nonlinear element of such ciphers, without them the algorithm would be trivial to break. Therefore, it is not surprising there exist a substantial body of work on the methods of constructing Boolean functions. Among those methods, evolutionary computation (EC) techniques play ...

The purpose of the present study was to investigate the effects of competitive NMDA receptor antagonists,D,L-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid (CGP 37849) and its ethyl ester (CGP 39551), or agonist, N-methyl-D-aspartate (NMDA) on spontaneous alternation in mice exposed to cerebral oligemia. Alternation behavior was evaluated in an Y-maze. Transient cerebral oligemic hypoxia was...

Pregnancy is associated with hemodynamic changes such as reduced vascular resistance and blood pressure. We reported that, during late pregnancy, the activity of voltage-dependent calcium channels (VDCC) is altered in the adrenal cortex and vascular smooth muscle. These observations suggested that the late pregnancy-induced decrease in blood pressure is linked to diminished VDCC function. We at...

Abstract Economic development in Sub Saharan African countries is strongly tied to households' ability cope with exogenous events affecting their well-being. Using data from the Lesotho Child Grant Program (CGP) we provide evidence on presence of any spillover effect program non-eligible households living treated villages and whether food security nutrition are influenced by a particular networ...

Acknowledgment: We wish to thanks Dr D.W. Cope for critical comments. This work was supported by the Fondation NRJ-Institut de France, the Wellcome Trust (grant 071436) and the Fondo de Investigaciones Sanitarias (grant 03/0177). D.R. is supported by the Ramón y Cajal program from MCYT, Spain. We wish to thank Novartis (Basel, Switzerland) for their gift of CGP 55845A and CGP 35348. Page 1 of 2...

CGP 9000, (7-[D-2-amino-2-(1,4-cyclohexadienyl)-acetamido]-3-methoxy-3-cephem-4-carboxylic acid), is a new broad-spectrum cephalosporin antibiotic. Its antibacterial activity in vitro (MIC) is similar, but its bactericidal efficacy superior to that of cephalexin and cephradine. Upon oral administration to mice infected with various bacteria, CGP 9000 is, in general, 2 to 7 times more effective ...

RATIONALE Aspartame (L-aspartyl phenylalanine methyl ester) is a non-nutritive sweetener (NNS) approved for use in more than 6000 dietary products and pharmaceuticals consumed by the general public including adults and children, pregnant and nursing mothers. However a recent prospective study reported a doubling of the risk of being overweight amongst 1-year old children whose mothers consumed ...