Multiple primary malignant neoplasms are rare entities in the clinical setting, but represent an important issue in the clinical management of patients since they could be expression of a genetic predisposition to malignancy. A high resolution genome wide array CGH led us to identify the first case of a de novo constitutional deletion confined to the FBXW7 gene, a well known tumor suppressor, i...

Over the past twenty years there has been an explosion in the creation, availability, and use of criminal justice databases. Large scale database systems now routinely influence law enforcement decisions ranging from formal determinations to arrest or convict an individual to informal judgments to subject a person to secondary pre-flight screening or investigate possible gang membership. Eviden...

The article shows how judicial review has expanded around the globe from the United States, Western Europe, and Japan to become a regular feature of constitutional design in Africa and Asia. Although the formal power to exercise judicial review is now nearly universal in democratic states, courts have varied in the extent to which they are willing to exercise this power in practice. After decad...

Red cell aplasia in children is a condition characterised by failure of erythropoiesis, with normal production of white blood cells and platelets. The disorder is either acquired or constitutional (congenital or inherited). The constitutional disorder is usually permanent, while the acquired variety is often transient, and thereby differs from adult pure red cell aplasia. As the treatment and p...

Red cell aplasia in children is a condition characterised by failure of erythropoiesis, with normal production of white blood cells and platelets. The disorder is either acquired or constitutional (congenital or inherited). The constitutional disorder is usually permanent, while the acquired variety is often transient, and thereby differs from adult pure red cell aplasia. As the treatment and p...

1. Define the ages at which puberty is considered delayed in boys and girls. 2. Discuss the typical presentation and natural history of constitutional delayed puberty. 3. Compare the differential diagnosis of delayed puberty for causes other than constitutional delay in girls versus boys. 4. Recognize the psychological consequences of pubertal delay. 5. Describe the evaluation and treatment of ...

Despite the former popularity of hypnosis as a way of "improving" eyewitness memory, many courts almost always regard the use of this testimony to be inadmissible, whereas others allow it only when strict procedural guidelines have been followed. Although the U.S. Supreme Court recognized a defendant's constitutional right to admit his own hypnotically elicited testimony, others have recognized...

While constitutions regulate political authority within a state, there is much we do not know about the interaction between political conditions and constitutional texts. Much of the literature relies upon hand-coded databases of constitutional texts. However, this approach raises both methodological and theoretical concerns. Advances in natural language processing, particularly latent text ana...

The relationship between parental constitutional chromosome abnormalities and the development of hydatidiform mole was evaluated in series from four institutions. Karyotype analysis was performed on blood samples from 237 patients with a pathological diagnosis of complete mole and 217 of their spouses. One patient was found to have a constitutional balanced translocation, t(11;18), while one sp...