Skeletal muscles belong to the musculoskeletal system, which is composed of bone, tendon, ligament and irregular connective tissue, and closely associated with motor nerves and blood vessels. The intrinsic molecular signals regulating myogenesis have been extensively investigated. However, muscle development, homeostasis and regeneration require interactions with surrounding tissues and the cel...

background: benign joint hypermobility syndrome (bjhs) is a disorder due to laxity of supporting connective tissue of joints. inguinal hernia is also proposed due to weak supporting tissue that may be a clinical presentation of a more widespread problem of connective tissue. materials and methods: in a cross-sectional study, prevalence of benign hypermobility joint syndrome (bhjs) was assessed ...

conclusions the results of the present study showed that tgf-β1 (-509) c/t is strongly associated with quantitative parameters of connective tissue constituents of interdental papilla in cp patients. results the volume density (vʋ) of epithelium, connective tissue, collagenous and non-collagenous matrix and blood vessels had statistically significant differences between the control and chronic ...

The mammalian skeletal muscle cell is very well investigated and the spatial arrangement of the molecules organizing it into sarcomeres, myofilaments, myofibril and myofibres can be considered as completely understood. It is also known that the structural integrity of muscle fibres is maintained by three layers of intramuscular connective tissue: the endomysium that surrounds the individual mus...

The reported prevalence and incidence of connective tissue disorders are quite variable, depending on differences in study methodology. Most important differences are the study duration, the classification criteria used for diagnosis and the country in which the study was undertaken. Sjögren's syndrome has the highest prevalence ranging between 0.5 and 3% of a given population. The prevalence o...

each excellent paper there is a discussion by the very distinguished members of the study group. The reviewer is, as might be surmised, in favor of disease-orientated research, believing that the application of basic science to clinical problems is the essence of modern medicine. He also believes that conferences such as this provide an opportunity for a valuable exchange of ideas. Unfortunatel...

ABSTRACT The biosynthesis of chondroitin sulphate exemplifies the formation of connective tissue polysaccharides. Six different glycosyltransferases participate: a chain-initiating xylosyltransferase, two galactosyltransferases, two glucuronosyltransferases, and an N-acetylgalactosaminyltransferase. Some of their properties are discussed, particularly their substrate specificities determined wi...

1. The action of excess of retinol on chick limb-bone rudiments cultured in chemically defined media has been investigated. 2. After 6 days in vitro, the hexosamine and hydroxyproline contents of the retinol-treated rudiments were much less than those of their paired controls. 3. Synthesis of these compounds, however, was not correspondingly decreased. 4. The control rudiments released hexosami...