BACKGROUND Autologous platelet-rich plasma (PRP) has been proven to be very effective on tissue regeneration and wound healing. Here we investigate the potential use of PRP in the treatment of symptomatic dry eye. METHODS Eighteen consecutive patients with symptomatic dry eye were treated with topical PRP and followed up for 1 month. Disappearance of subjective symptoms, increase in best corr...

This report documents a case of T cell lymphoma manifesting only with a conjunctival mass. A 67-year-old man underwent a diagnostic punch biopsy, histopathological examination, and immunohistochemical study for a pink-yellow colored mass infiltrating the bulbar conjunctiva in the lower fornix of the eyelid. A biopsy specimen of the conjunctival mass was found histopathologically to be a maligna...

PURPOSE To determine the expression and function of toll-like receptors (TLRs) in human conjunctival, limbal and corneal epithelial cells. METHODS Expression of TLRs was examined by real-time polymerase chain reaction, immunohistochemistry, and western blot analysis in human conjunctival, corneal and limbal epithelial cells and tissues. Ligand-stimulated nuclear factor kappaB activation; inte...

Papillomas of the conjunctival surface in people can be of viral or nonviral origin and are found in high association with human papillomavirus. Canine conjunctival papillomas are seldom described, and published accounts have mostly been associated with canine oral papillomavirus infection. Here, we describe conjunctival squamous papillomas that do not express papillomavirus proteins and compar...

Aims: To describe the results of a study of the incidence of conjunctival ulceration and its pathology as a manifestation of Behçet’s syndrome. Methods: The authors reviewed retrospectively medical charts of 152 patients with Behçet’s syndrome seen at the uveitis service of Okayama University Hospital from January 1995 to December 1999. Criteria used to diagnose Behçet’s syndrome in this study ...

The conjunctiva can be damaged by numerous diseases with scarring, loss of tissue and dysfunction. Depending on extent damage, restoration function may require a conjunctival graft. A wide variety biological synthetic substrates have been tested in the search for optimal conditions ex vivo culture epithelial cells as route toward grafts. Each substrate has specific advantages but also disadvant...

PURPOSE To investigate conjunctiva-associated lymphoid tissue (CALT) in mouse conjunctiva. METHOD We examined normal mice, ranging in age from 4 to 6 weeks, to investigate the presence of follicular tissue histologically. Next, we treated mice by topical instillation of ovalbumin and cholera toxin B, and then examined conjunctival follicles by immunohistological methods. RESULTS Follicular ...

Conjunctival ulceration accompanied with secretion and pain was observed in a 30-year-old male, 3 days after a perforating corneal trauma. Cultures of conjunctival ulcer samples grew Fonsecaea pedrosoi, a major causative agent of chromoblastomycosis that is typically transmitted during trauma. The conjunctival ulcer was successfully treated with amphotericin B, itraconazole, and fluconazole. Th...