Differential cell death is a common feature of aging and age-related disease. In the retina, 30% of rod photoreceptors are lost over life in humans and rodents. However, studies have failed to show age-related cell death in mouse cone photoreceptors, which is surprising because cone physiological function declines with age. Moreover in human, differential loss of short wavelength cone function ...

In vitro studies conducted in Aplysia and chick sensory neurons indicate that in addition to microtubule assembly, long microtubules in the C-domain of the growth cone move forward as a coherent bundle during axonal elongation. Nonetheless, whether this mode of microtubule translocation contributes to growth cone motility in vivo is unknown. To address this question, we turned to the model syst...

A bstract The holographic entropy cone characterizes the relations between entanglement entropies for a spatial partitioning of boundary spacetime CFT in any state describing classical bulk geometry. We argue that cone, an arbitrary number parties, can be reconstructed from more fundamental data determined solely by subadditivity quantum entropy. formulate certain conjectures about graph models...

OBJECTIVE To assess the diagnostic potential of 2 different cone-beam computerized tomography (CT) units and compare this with intraoral digital and conventional film in the detection of chemically created periapical lesions. STUDY DESIGN Periapical lesions were created chemically in 27 intact roots of 23 teeth (6 incisors, 4 canines, 6 premolars, and 7 molars). Cone-beam CT and digital and f...

Coherent backscattering (CBS) is a beautiful physical phenomenon that takes place in a highly scattering medium, which has potential application in noninvasive optical property measurement. The current model that explains the CBS cone shape, however, assumes the incoming beam diameter is infinitely large compared to the transport length. In this paper, we evaluate the effect of a finite scalar ...

Retinitis pigmentosa (RP) is an inherited photoreceptor degenerative disorder that results in blindness. The disease is often caused by mutations in genes that are specific to rod photoreceptors; however, blindness results from the secondary loss of cones by a still unknown mechanism. Here, we demonstrated that the mammalian target of rapamycin complex 1 (mTORC1) is required to slow the progres...

Serotiny is an important adaptation for plants in fire-prone environments. However, different mechanisms also induce the opening of serotinous cones in the absence of fire in variably serotinous species. Xeriscence -cone opening driven by dry and hot conditions- is considered to be mediated only by the external environment, but endogenous factors could also play a significant role. Using the va...

The dynamics of gas flow through spinning cone columns (SCCs) have been studied through Computational Fluid Dynamics (CFD) simulations, and the liquid flow characteristics on the rotating surfaces have been correlated through dimensional analysis. The CFD simulations have been carried out in the absence of liquid flow. Flow instabilities are predicted above a critical value of the hydraulic Rey...

In this paper we study several issues related to the characterization of specific classes of multivariate quadratic mappings that are nonnegative over a given domain, with nonnegativity defined by a pre-specified conic order. In particular, we consider the set (cone) of nonnegative quadratic mappings defined with respect to the positive semidefinite matrix cone, and study when it can be represe...

Recently, models of two-dimensional dilaton gravity have been shown to admit classical black-hole solutions that exhibit Hawking radiation at the semi-classical level. These classical and semi-classical analyses have been performed in conformal gauge. We show in this paper that a similar analysis in the light–cone gauge leads to the same results. Moreover, quantization of matter fields in light...