OBJECTIVE The transfer of abacavir, a new nucleoside inhibitor, and amprenavir, a new protease inhibitor, used for the treatment of human immunodeficiency virus, has been studied in the ex vivo human placental model. METHODS The ex vivo human placental model used C14 antipyrine to determine the transport fraction and clearance index of these compounds at both the peak and trough serum concent...

background: health inequalitymonitoring especially in health care financing field is very important. hence, this study tends to assess the inequality in household's capacity to pay and out-of-pocket health carepaymentsin tehran metropolis. methods: this cross-sectional study was performed in 2013.thestudy population was selected by stratified cluster sampling, and they constitute the typic...

BACKGROUND AND AIMS Quercetin is a flavonoid with good antioxidant activity, and exhibits various important pharmacological effects. The aim of the present work was to study the influence of formulation factors on the physicochemical properties of quercetin-loaded polymeric nanoparticles in order to optimize the formulation. MATERIALS AND METHODS The nanoparticles were prepared by the nanopre...

The auditory evoked potential (AEP) is correlated to anaesthetic depth. The AEP has been used in rats, pigs, dogs and humans to assess anaesthetic depth. This study was undertaken to determine whether the AAI Index derived from the AEP correlated with changes in end tidal isoflurane concentration in dogs. The average AAI Index was 21.8 +/- 10.5 and isoflurane concentration was 1.7 +/- 0.4%. Dat...

Inequality in access to quality healthcare is a major health policy challenge in many low- and middle-income countries. This study aimed to identify the major sources of inequity in healthcare utilization using a population-based household survey from urban Nepal. A cross-sectional survey was conducted covering 9177 individuals residing in 1997 households in five municipalities of Kathmandu val...

BACKGROUND To guide anesthetic administration with electroencephalogram monitors in children, an adequate characterization of the anesthetic effect measured by these monitors in this population is needed. We sought to quantify and compare the dynamic profile of sevoflurane's effect measured with the cerebral state index (CSI) and the bispectral index (BIS) in children. METHODS Fifteen healthy...

drastic model has been used to map groundwater vulnerability to pollution in many areas. since this method is used in different places without any changes, it cannot consider the effects of pollution type and characteristics. therefore, the method needs to be calibrated and corrected for a specific aquifer and pollution. in the present research, the rates of drastic parameters have been correct...

in the recent years, agricultural soils have received more chemicals in various forms for higher yields. this may result in the accumulation of metals in soils which subsequently may be transferred into the agricultural crops. in the present investigation, nickel content of 58 composite soil samples and also agricultural crops, is studied. ni in samples of soil and agricultural products were ex...