Targeting the Hedgehog (Hh) pathway represents a potential leukaemia stem cell (LSC)-directed therapy which may compliment tyrosine kinase inhibitors (TKIs) to eradicate LSC in chronic phase (CP) chronic myeloid leukaemia (CML). We set out to elucidate the role of Hh signaling in CP-CML and determine if inhibition of Hh signaling, through inhibition of smoothened (SMO), was an effective strateg...

An organism's awareness of its surroundings is dependent on sensory function. As antennas to our external environment, cilia are involved in fundamental biological processes such as olfaction, photoreception, and touch. The olfactory system has adapted this organelle for its unique sensory function and optimized it for detection of external stimuli. The elongated and tapering structure of olfac...

pragmatic assessment and consistency in rating are among the subject matters which are still in need of more profound investigations. the importance of the issue is highlighted when remembering that inconsistency in ratings would surely damage the test fairness issue in assessment and lead to much diversity in ratings. our principal concern in this study was observing the criteria that american...

Abstract AIMS High grade gliomas are the most common CNS malignancies and cause ~200,000 deaths/year globally. Glioblastoma (WHO IV) confer worst prognoses with their treatment being hindered by glioma stem cell-like (GSC) tumour sub-regions high intratumoural spatio-heterogeneity. Tumour Treating Fields (TTFields) exert clinically approved alternating electric fields of intermediate frequency ...

A new divide-and-conquer technique for disparity estimation is proposed in this paper. This technique performs feature matching recursively, starting with the strongest feature point in the left scanline. Once the rst matching pair is established, the ordering constraint in disparity estimation allows the original intra-scanline matching problem to be divided into two smaller subproblems. Each ...

The identiication of aspects of cepstral features that contain a high degree of speaker speciicity potentially can simplify the task of speaker recognition. The identiication process can be performed both temporally and cepstrally. The temporal analysis determines which phonemes or utterances exhibit the highest degree of speaker speciicity, while the cepstral analysis examines individual cepst...

Since the discovery of the NICMOS count rate dependent non-linearity documented in NICMOS ISR 2005-002, additional tests have been conducted to further understand and quantify the effect. Long integrations of up to 25 minutes exhibited the same level of non-linearity as the original 1-3 minute integrations. Observations of the star P041C on high background from an internal flat field lamp provi...

Until now the main purpose of Distributed Energy Resources (DERs) has been to compliment the power plants. However, if DERs are to play a larger role in the power grid of the future, then improved communication and cooperation between these resources and the system operators is necessary. Cooperation requires intelligence at the level of the DER as well as at the aggregator level, and in order ...

GENERAL COMMENTS First, I would like to compliment the authors on their research – understanding how the general public is exposed to important health issues through mass media is a key step towards the development of health communication and interventions to promote healthy behavior. I like that the authors recognized the variation in scope and reach across newspapers, and discussed the findin...

Although assessment-based approaches and measurement-based approaches are often considered as competitors, they compliment each other very well. Assessments are strong in identifying improvement objectives within a relatively short time frame, but are weak in guiding the actual implementation of the proposed changes. Measurement, however, supports very well in supporting actual changes and prov...