BACKGROUND There are no consistent agreements on whether radiotherapy after breast-conserving surgery (BCS) could provide local control and survival benefit for older patients with early breast cancer or breast ductal carcinoma in situ (DCIS). The present study aimed to evaluate the efficacy of radiotherapy after BCS in older patients with early breast cancer or DCIS. RESULTS Radiotherapy cou...

INTRODUCTION The main purpose of emergency department (ED) management for renal colic is prompt pain relief. The present study aimed to compare the analgesic effects of intravenus (IV) ketofol with morphine in management of ketorolac persistent renal colic. METHODS This study is a single blind randomized, clinical trial, on patients who were presented to ED with renal colic, whose pain was re...

Anti-tumour necrosis factor (TNF) agents are recommended as second-line therapy for patients with axial spondyloarthropathies. This analysis reviewed data on studies investigating the efficacy and tolerability of anti-TNF agents in patients with non-radiographic axial spondyloarthritis (nr-axSpA) who had failed first-line non-steroidal anti-inflammatory (NSAID) treatment. Efficacy data from RCT...

Objective. Examine the effects of exercise on femoral neck (FN) and lumbar spine (LS) bone mineral density (BMD) in premenopausal women. Methods. Meta-analysis of randomized controlled exercise trials ≥24 weeks in premenopausal women. Standardized effect sizes (g) were calculated for each result and pooled using random-effects models, Z score alpha values, 95% confidence intervals (CIs), and nu...

BACKGROUND Chinese herbal medicine has been used to treat millions of people with schizophrenia for thousands of years. AIMS To evaluate Chinese herbal medicine as a treatment for schizophrenia. METHOD A systematic review of randomised controlled trials (RCTs). RESULTS Seven trials were included. Most studies evaluated Chinese herbal medicine in combination with Western antipsychotic drug...

OBJECTIVE To perform a systematic review and meta-analysis to determine whether taking antiemetic drugs reduces vomiting and decreases the need for further intervention in children with gastroenteritis without causing significant adverse effects. DATA SOURCES Computerized databases, reference lists, and expert recommendations. STUDY SELECTION Prospective controlled trials evaluating medicat...

I completely concur with Dr Des Spence: Big Pharma is manipulating doctors and exploiting patients, and Big Medicine is neglecting its role to protect patients.1 I can remember, shortly after becoming a GP Principal in 1987, a drug representative trying to persuade us to prescribe evening primrose oil capsules for itching in eczema. The glossy presentation and neurolinguistic programming attemp...

Two mesoscale numerical weather prediction models, Eta and the Rapid Update Cycle (RUC), are currently being run operationally at the U.S. National Weather Service’s National Meteorological Center to produce nationwide weather forecasts. Improvements in weather forecast accuracy depend on increasing model resolution, which is limited by available computing resources. Massively Parallel Processi...

BACKGROUND Studies that are the basis of recommended volume thresholds for CABG surgery are outdated and not reflective of recent advances in the field. This study examines both hospital and surgeon volume-mortality relations for CABG surgery through the use of a population-based clinical data set. METHODS AND RESULTS Data from New York's clinical CABG surgery registry from 1997 to 1999 (tota...

BACKGROUND Anxiety and depression in children and adolescents are undertreated. Computer- and Internet-based cognitive behavioral treatments (cCBT) may be an attractive treatment alternative to regular face-to-face treatment.This meta-analysis aims to evaluate whether cCBT is effective for treating symptoms of anxiety and depression in youth. METHODS AND FINDINGS We conducted systematic searc...