نتایج جستجو برای: comfa region focusing

تعداد نتایج: 631252  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه زابل - دانشکده علوم پایه 1393

مطالعه کیوسار سه بعدی بر روی برخی بازدارنده های غیرپپتیدی پروتئین تیروزین فسفاتاز( step) بعنوان داروهای ضد آلزایمر توسط روش های تحلیل مقایسه ای میدان مولکولی (کومفا) و تحلیل مقایسه ای شاخص های شکل مولکولی (کومسیا) برای تعیین فاکتورهایی که در بروز فعالیت در این ترکیبات ضرورت دارد، انجام گرفت. در روش بر خط کردن دیستیل به عنوان روش نهایی برای تراز کردن مولکول ها در نظر گرفته شد. در بررسی قدرت پیشگ...

Journal: :Journal of neurology, neurosurgery, and psychiatry 1974
K G Kjellin H Stibler

The protein patterns found on isoelectric focusing and quantitative paper electrophoresis of cerebrospinal fluid were studied in three patients with spasmodic torticollis. Very alkaline end fractions were found on isoelectric focusing in the CSF-gammaglobulin region in each case. Alkaline end fractions in the CSF-gammaglobulin region with similar or same isoelectric points have also been observ...

Journal: :Journal of medicinal chemistry 1994
A N Jain K Koile D Chapman

We describe a new method, Compass, for predicting the biological activities of molecules based on the activities and three-dimensional structures of other molecules. The method improves on previous techniques by representing only the surface of molecules, by incorporating a nonlinear statistical method, and by automatically choosing conformations and alignments of molecules. We use a benchmark ...

2013
Shaya Karimkashi Ahmed A. Kishk Darko Kajfez Guifu Zhang David L. Boren

Some new focusing properties of time-domain ultra wide band (UWB) focusing array antennas are presented. The large current radiator (LCR) is considered as the UWB antenna element. Each LCR is replaced by a set of infinitesimal dipoles modeling both the near field and the far field patterns of the antenna element, as well as the coupling between the elements. Several antenna arrays with differen...

Journal: Iranian Economic Review 2018

This paper examines the possible choices and energy security plans of China, focusing on its relations with I.R Iran and Saudi Arabia in the Middle East. Needless to say, these two rival countries in the region are both among the top oil producers of the world and China has deep and old cooperation with both countries. Meanwhile in its new strategy, China tries to establish a kind of balance am...

Journal: :Langmuir : the ACS journal of surfaces and colloids 2011
Noah G Weiss Mark A Hayes Antonio A Garcia Rafat R Ansari

A novel approach to molecular separations is investigated using a technique termed droplet-based isoelectric focusing. Drops are manipulated discretely on a superhydrophobic surface, subjected to low voltages for isoelectric focusing, and split-resulting in a preparative separation. A universal indicator dye demonstrates the generation of stable, reversible pH gradients (3-10) in ampholyte buff...

Journal: :Journal of medicinal chemistry 2001
X Huang T Liu J Gu X Luo R Ji Y Cao H Xue J T Wong B L Wong G Pei H Jiang K Chen

With flavone as a structural template, three-dimensional quantitative structure-activity relationship (3D-QSAR) studies and ab initio calculations were performed on a series of flavonoids. A reasonable pharmacophore model was built through CoMFA, CoMSIA, and HQSAR analyses and electrostatic potential calculations. A plausible binding mode for flavonoids with GABA(A) receptors was rationalized. ...

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