Soon after birth the mammalian gut microbiota forms a permanent and collectively highly resilient consortium. There is currently no robust method for re-deriving an already microbially colonized individual again-germ-free. We previously developed the in vivo growth-incompetent E. coli K-12 strain HA107 that is auxotrophic for the peptidoglycan components D-alanine (D-Ala) and meso-diaminopimeli...

In view of the increasing evidence that glucosphingolipids (GSLs) on tumor cell surfaces play an important role in tumor metastasis, an inhibitor of glucosylceramide synthase, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP) was used to evaluate the role of GSLs in this respect. Treatment of Lewis lung carcinoma cells with 5 microM D-PDMP resulted in a time-dependent marked dec...

Abstract Background Scientific approaches into modern agricultural systems, as opposed to the use of synthetic pesticides in food production, became important by exploring endophytic fungi capable protecting plants against pathogens for maximum crop productivity. Main body Diverse microbes colonizing internal tissue exhibit beneficial and pathological effects on plants. The assisted control pat...

Non-host resistance (NHR) is a broad-spectrum plant defense. Upon colonizing on the surface on the root or leaves of non-host species, pathogens initial encounter preform and induce defense response in plant, such as induced hypersensitive response, PAMPs triggered immunity (PTI), and effector triggered immunity (ETI). The ability of plants to develop an induced systemic response (ISR) in react...

Anoxybacillus strain BCO1, isolated from a thermophilic (50°C) microbial mat colonizing an outflow of a Great Artesian bore well of Australia, possessed a genome of ~2.8 Mb, with a G+C content of 41.7 mol%, and encoded 3,205 genes.

The human skin microbiome could provide another example, after the gut, of the strong positive or negative impact that human colonizing bacteria can have on health. Deciphering functional diversity and dynamics within human skin microbial communities is critical for understanding their involvement and for developing the appropriate substances for improving or correcting their action. We present...

Pseudomonas fluorescens UM270 is a rhizosphere-colonizing bacterium that produces multiple diffusible and volatile compounds involved in plant growth-promoting activities. Strain UM270 exhibits excellent biocontrol capacities against diverse fungal pathogens . In a previous study, the general UM270 genome characteristics were published. Here, we report a deeper analysis of its gene content and ...

Thirty-two isolates of Fusarium from Hawaiian Acacia koa exhibiting wilt/dieback disease symptoms were compared for their pathogenic potential on young Douglas-fir germinants in controlled laboratory tests. Only three isolates (one each of F. oxysporum, F. solani, and F. subglutinans) exhibited low virulence. All others, including isolates of F. semitectum and F. equiseti, were non-pathogenic. ...

Plastic debris has been accumulating in the marine realm since start of plastic mass production 1950s. Due to adverse effects on ocean life, fate plastics environment is an increasingly important environmental issue. Microbial degradation, addition weathering, identified as a potentially relevant breakdown route for debris. Although many studies have focused microbial colonization and potential...