iatrogenic perforation of the colon during elective colonoscopy is a serious complication. surgical treatment remains the standard of care. we report a patient with a large colonic perforation that occurred during a screening colonoscopy, successfully repaired with laparoscopic methods. although the safety and efficacy of this approach is not entirely established, laparoscopy can be used to tre...

A novel experimental pHand time-dependent colonic drug delivery system was prepared and its in vitro and in vivo performances were evaluated. The colonic delivery system consists of minitablets with a big swelling capacity coated with an inlet retardant layer insoluble at all pH ranges but permeable (Eudragit RS 30D) and an outlet layer, insoluble and impermeable at acidic pH but easily soluble...

Isolated perfused segments of pig ileum and sigmoid colon were used as an extrinsically denervated model of intestinal fluid propulsion to compare the effects of intraluminal (IL) with intraarterial (IA) administration of cisapride and mebeverine. The ileal segments had a spontaneous mean activity of 0.008 (SEM 0.003) ml Krebs propelled aborally min-1, with propulsive waves at a mean frequency ...

Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key transcriptional regulator for antioxidant and anti-inflammation enzymes that binds to its endogenous inhibitor protein, Kelch-like ECH (erythroid cell-derived protein with CNC homology)-associated protein 1, in the cytoplasm under normal conditions. Various endogenous or environmental oxidative stresses, such as ionizing radiation (IR)...

BACKGROUND Nanoliposomes are designed as carriers capable of packaging drugs through passive targeting tumor sites by enhanced permeability and retention (EPR) effects. In the present study the biodistribution, pharmacokinetics, micro single-photon emission computed tomography (micro-SPECT/CT) image, dosimetry, and therapeutic efficacy of (188)Re-labeled nanoliposomes ((188)Re-liposomes) in a C...

Some, but not all, studies have suggested that high-fat diets promote colon carcinogenesis, possibly by stimulating the proliferative activity of colonic epithelium. Both the increase in colonic excretion of bile salts and of fatty acids that occur with an increase in fat ingestion have been implicated as stimuli of epithelial proliferative activity. In this study, we examined the role of activ...

Manometric and pharmacological tests have shown that motor abnormalities may occur in the non-dilated colons of chagasic patients. In order to investigate the presence of abnormalities of colonic function in constipated patients with Chagas' disease (ChC) without megaesophagus or megacolon, studies of total and segmental colonic transit time with radiopaque markers were performed on 15 ChC pati...

Lesson Colonic lipomas are rare benign tumours that usually asymptomatic. However, giant colonic tend to be symptomatic and can occasionally result in intussusception intermittent obstruction. As adult is an uncommon occurrence, the identification of underlying aetiology essential due its high association with malignancy. Computed Tomography remains tool choice for diagnosis lipomas. Surgical e...

the purpose of this study, determining the optimal cultivation pattern by using interval mathematical programming approach among the farmers of esfarayen county before and after targeting the subsidies. for this purpose, farmers based on water resources classified in three group of using the river water, deep wells water and rainfed cultivation. the required data for this study has been obtaine...